{"id":"W4389108274","doi":"10.1038/s41588-026-02586-y","title":"H3K27me3 spreading organizes canonical PRC1 chromatin architecture to regulate developmental programs","year":2023,"lang":"en","type":"preprint","venue":"Nature Genetics","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":5,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université de Montréal; Centre Hospitalier Universitaire Sainte-Justine; Alberta Children's Hospital; McGill University Health Centre; University of Toronto; Jewish General Hospital; Hospital for Sick Children; McGill Genome Centre; University of Calgary; McGill University","funders":"Fonds de Recherche du Québec - Santé; Natural Sciences and Engineering Research Council of Canada; Fondation Charles-Bruneau; National Institutes of Health; Government of Canada; Government of Ontario; St. Jude Children's Research Hospital; Compute Canada; Canadian Institutes of Health Research; Genome Canada","keywords":"Chromatin; Architecture; Computer science; Biology; Communication; Psychology; Genetics; History; DNA","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001837024,0.0002858614,0.000229466,0.0002928377,0.0002114275,0.0008334905,0.0004219062,0.000314734,0.004178214],"category_scores_gemma":[0.0003900152,0.0003907242,0.0002739864,0.0002915798,0.0003456102,0.0004308848,0.0006561617,0.000471319,0.002021512],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005212784,"about_ca_system_score_gemma":0.0002650612,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001121861,"about_ca_topic_score_gemma":0.002440324,"domain_scores_codex":[0.9998742,0.000006521695,0.000003167442,0.00003920099,0.00004096601,0.00003575385],"domain_scores_gemma":[0.9998891,0.0000162228,0.00001822293,0.00002696428,0.00002153722,0.0000278714],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0002274202,0.00001280692,0.00370762,0.00005743528,0.00002967003,0.0001445954,0.00006334509,0.00290363,0.9680904,0.007057311,0.001219405,0.01648628],"study_design_scores_gemma":[0.00005211175,0.00005974755,0.04094188,0.000009616125,0.00003577061,0.000311936,0.0000980594,0.04691469,0.8938977,0.008854833,0.008791707,0.00003202313],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.902989,0.001255156,0.07454836,0.0003813297,0.0001627795,0.00002360431,0.0008495376,0.001482091,0.01830816],"genre_scores_gemma":[0.9854197,0.0003132663,0.005153553,0.00005822914,0.00002537596,0.00001072555,0.0004624757,0.000293404,0.008263235],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004178214,"threshold_uncertainty_score":0.01397759,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01761849928890738,"score_gpt":0.2874091932468745,"score_spread":0.2697906939579671,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}