{"id":"W4389116858","doi":"10.1093/ofid/ofad596","title":"5-Flucytosine Longitudinal Antifungal Susceptibility Testing of <i>Cryptococcus neoformans</i>: A Substudy of the EnACT Trial Testing Oral Amphotericin","year":2023,"lang":"en","type":"article","venue":"Open Forum Infectious Diseases","topic":"Fungal Infections and Studies","field":"Medicine","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity","funders":"National Institute of Neurological Disorders and Stroke; Fogarty International Center; National Institute of Allergy and Infectious Diseases","keywords":"Flucytosine; Amphotericin B; Cryptococcus neoformans; Medicine; Cryptococcosis; Cryptococcus; Broth microdilution; Meningitis; Microbiology; Minimum inhibitory concentration; Pharmacology; Internal medicine; Antimicrobial; Biology; Immunology; Surgery; Antifungal","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.005189641,0.000916494,0.002060642,0.0003139599,0.0005397607,0.0009953955,0.0005417077,0.001112607,0.001470185],"category_scores_gemma":[0.003660911,0.000356624,0.001884436,0.000599837,0.0006187476,0.0006343802,0.0004950924,0.001591781,0.0003198019],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007814785,"about_ca_system_score_gemma":0.001060129,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001846581,"about_ca_topic_score_gemma":0.003028861,"domain_scores_codex":[0.9969828,0.002049217,0.0002369976,0.0002891086,0.0001899358,0.0002520304],"domain_scores_gemma":[0.9962852,0.001000066,0.001071887,0.0003711248,0.0006292224,0.0006425507],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"observational","study_design_scores_codex":[0.8821996,0.005514774,0.05014862,0.002061536,0.006470968,0.0001351815,0.0002799939,0.0005432785,0.01157256,0.0001630123,0.002288775,0.03862178],"study_design_scores_gemma":[0.3072424,0.48587,0.1651879,0.0008300372,0.01692318,0.0006946056,0.0003325671,0.001189095,0.01015752,0.0003247247,0.0111212,0.0001267388],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9843853,0.009312553,0.0004711442,0.000330942,0.0001512645,0.001699219,0.00183008,0.00003019784,0.001789328],"genre_scores_gemma":[0.9937981,0.001789335,0.0004927166,0.0003411998,0.0001532718,0.001348197,0.001481573,0.000007304031,0.0005882793],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005189641,"threshold_uncertainty_score":0.02744579,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06986031924837863,"score_gpt":0.3321880576068607,"score_spread":0.262327738358482,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}