{"id":"W4389127810","doi":"10.1126/scitranslmed.abo5217","title":"Radiation-induced bone loss in mice is ameliorated by inhibition of HIF-2α in skeletal progenitor cells","year":2023,"lang":"en","type":"article","venue":"Science Translational Medicine","topic":"Management of metastatic bone disease","field":"Medicine","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"National Institute of Arthritis and Musculoskeletal and Skin Diseases; National Cancer Institute; National Institute on Aging; National Institutes of Health","keywords":"Progenitor cell; Progenitor; Bone marrow; Cancer research; Medicine; Endocrinology; Chemistry; Cell biology; Internal medicine; Pharmacology; Stem cell; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001493777,0.0001455927,0.0003294099,0.001179296,0.00004822502,0.000006226835,0.0001109306,0.00004064459,0.0003747409],"category_scores_gemma":[0.0002382086,0.0001305931,0.00004044667,0.004887382,0.0004710941,0.0002746433,0.00001370212,0.0001502907,0.00004752546],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006324865,"about_ca_system_score_gemma":0.0003287506,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001497532,"about_ca_topic_score_gemma":0.00001726059,"domain_scores_codex":[0.99719,0.0000535664,0.0006517007,0.0003957266,0.001389362,0.0003196339],"domain_scores_gemma":[0.999242,0.0001142787,0.0001376789,0.0001672235,0.0001697738,0.0001690097],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0001615061,0.0003528609,0.02034572,0.0002612215,0.00001482403,0.00008205126,0.002202617,0.00007343889,0.9682034,0.000354541,0.002137483,0.005810314],"study_design_scores_gemma":[0.02216185,0.0008551215,0.72742,0.001448462,0.0002087407,0.00001570694,0.002403785,0.0362964,0.2045766,0.002985095,0.001053352,0.0005748962],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9824728,0.000195276,0.000145956,0.0156454,0.0001800243,0.0008347158,0.00004474575,0.00003818996,0.0004428601],"genre_scores_gemma":[0.9986386,0.00004205535,0.0004285005,0.0004541714,0.00006269787,0.00003569147,0.0001906777,0.00001216247,0.0001354332],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.7636268,"threshold_uncertainty_score":0.5325432,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02280627129034231,"score_gpt":0.3120938236514571,"score_spread":0.2892875523611148,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}