{"id":"W4389130660","doi":"10.1136/jitc-2023-007353","title":"Phase I/Ib, open-label, multicenter, dose-escalation study of the anti-TGF-β monoclonal antibody, NIS793, in combination with spartalizumab in adult patients with advanced tumors","year":2023,"lang":"en","type":"article","venue":"Journal for ImmunoTherapy of Cancer","topic":"TGF-β signaling in diseases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":38,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre","funders":"Novartis Pharmaceuticals Corporation","keywords":"Medicine; Rash; Adverse effect; Internal medicine; Cohort; Colorectal cancer; Lung cancer; Monoclonal antibody; Gastroenterology; Antibody; Cancer; Oncology; Immunology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000170068,0.0001431495,0.00023781,0.0001097816,0.00008028353,0.00002531835,0.0003200154,0.00004506426,0.000006280648],"category_scores_gemma":[0.00002692146,0.0000977947,0.00003663157,0.000276459,0.00005969165,0.00003125474,0.0000409482,0.00009802521,1.177534e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004526602,"about_ca_system_score_gemma":0.00015935,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000124202,"about_ca_topic_score_gemma":0.0004692611,"domain_scores_codex":[0.9988348,0.00007984501,0.0004414788,0.0001903731,0.0002746282,0.0001789126],"domain_scores_gemma":[0.9989405,0.00001975373,0.0004917838,0.0002000917,0.0003210903,0.00002674361],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.01697532,0.009503549,0.6160464,0.00005850501,0.0002579077,0.000002835564,0.0008771053,0.008495185,0.3350016,0.000005018349,0.00005602456,0.01272062],"study_design_scores_gemma":[0.1056363,0.007120544,0.7865084,0.0005848891,0.00003329472,0.00000152364,0.0004811875,0.0008367042,0.09833696,0.00001882024,0.0002213002,0.0002201001],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9981936,0.0002959542,0.00006263239,0.00004865284,0.0001401421,0.001211275,0.00004054117,0.000003453432,0.000003728323],"genre_scores_gemma":[0.9994,0.000152858,0.0001740118,0.00004158531,0.00001908904,0.00009389489,0.00005751506,0.00003065298,0.00003043693],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2366646,"threshold_uncertainty_score":0.3987952,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01604813275007517,"score_gpt":0.3554961998091867,"score_spread":0.3394480670591116,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}