{"id":"W4389134982","doi":"10.7554/elife.89331.4.sa3","title":"Author Response: PI(3,4,5)P3 allosteric regulation of repressor activator protein 1 controls antigenic variation in trypanosomes","year":2023,"lang":"en","type":"peer-review","venue":"","topic":"Trypanosoma species research and implications","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University","funders":"","keywords":"Repressor; Allosteric regulation; Activator (genetics); Pi; Antigenic variation; Antigen; Biology; Cell biology; Chemistry; Genetics; Gene; Biochemistry; Receptor; Transcription factor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003107664,0.0003922367,0.0004941883,0.0007207663,0.001236911,0.002550363,0.0007874419,0.003039333,0.1554111],"category_scores_gemma":[0.0295629,0.0002197306,0.0002476077,0.0004850275,0.00089417,0.0008921008,0.001548803,0.002168789,0.03756483],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001277072,"about_ca_system_score_gemma":0.003245362,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001799543,"about_ca_topic_score_gemma":0.004129785,"domain_scores_codex":[0.9975572,0.0005858652,0.0001386094,0.0002603232,0.001122511,0.0003354963],"domain_scores_gemma":[0.980135,0.004086617,0.0009348513,0.0006512076,0.01138663,0.002805639],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0004408974,0.00003144304,0.001449104,0.0003051878,0.00002288651,0.0004405346,0.0002790044,0.0001451757,0.004285678,0.003280335,0.9611914,0.02812834],"study_design_scores_gemma":[0.0001049584,0.0001076878,0.004843131,0.0001275869,0.00002183806,0.0003715458,0.001208758,0.0004278565,0.004582097,0.003673921,0.9844901,0.00004047643],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"commentary","genre_gemma":"commentary","genre_scores_codex":[0.02100377,0.003256213,0.003059825,0.6475242,0.2453444,0.0003116105,0.001949208,0.001081385,0.07646952],"genre_scores_gemma":[0.1142281,0.003876254,0.002009189,0.08918229,0.0461936,0.0001565292,0.001901499,0.0006884749,0.741764],"genre_candidate":"commentary","genre_consensus":"commentary","teacher_disagreement_score":0.1554111,"threshold_uncertainty_score":0.5199021,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07456160353256129,"score_gpt":0.3889211462771313,"score_spread":0.31435954274457,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}