{"id":"W4389137771","doi":"10.1016/j.oret.2023.11.015","title":"Outcomes of Treatment-Resistant Neovascular Age-Related Macular Degeneration Switched from Aflibercept to Faricimab","year":2023,"lang":"en","type":"article","venue":"Ophthalmology Retina","topic":"Retinal Diseases and Treatments","field":"Medicine","cited_by":57,"is_retracted":false,"has_abstract":false,"ca_institutions":"Public Health Ontario; University of Toronto","funders":"Roche; Bayer","keywords":"Aflibercept; Medicine; Macular degeneration; Ophthalmology; Visual acuity; Retrospective cohort study; Pro re nata; Regimen; Ranibizumab; Surgery; Bevacizumab; Chemotherapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003584059,0.0001809275,0.0005354836,0.0002458737,0.0002906168,0.0006804477,0.0002549182,0.0003572016,0.001747219],"category_scores_gemma":[0.001571763,0.00007255925,0.001258783,0.0003752997,0.0002281708,0.0004959041,0.0002464412,0.000864986,0.0001913784],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009368378,"about_ca_system_score_gemma":0.0003826022,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002432951,"about_ca_topic_score_gemma":0.002381566,"domain_scores_codex":[0.9996614,0.00006680253,0.00003299738,0.0000578852,0.00005857435,0.000122244],"domain_scores_gemma":[0.9993744,0.0001682361,0.0001987038,0.00004164431,0.00005797785,0.0001589727],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.183841,0.004916064,0.5894362,0.0006550777,0.004581017,0.003761112,0.0005704744,0.0026014,0.006787009,0.0009447379,0.004880059,0.1970258],"study_design_scores_gemma":[0.004890667,0.0240845,0.9573692,0.000140262,0.00253319,0.002794168,0.000669167,0.00219208,0.001230724,0.001071578,0.002957928,0.00006651446],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9976717,0.000915675,0.00003783481,0.0000910786,0.00002880103,0.00001364534,0.0002625154,0.00000277151,0.0009760827],"genre_scores_gemma":[0.9990246,0.0002176035,0.00001799343,0.00007566591,0.00003059869,0.00001037828,0.0003990321,0.000001211535,0.0002228331],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002432951,"threshold_uncertainty_score":0.006797254,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03038580533603273,"score_gpt":0.3184912470966196,"score_spread":0.2881054417605868,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}