{"id":"W4389138908","doi":"10.1080/15548627.2023.2288528","title":"CARM1 drives mitophagy and autophagy flux during fasting-induced skeletal muscle atrophy","year":2023,"lang":"en","type":"article","venue":"Autophagy","topic":"Autophagy in Disease and Therapy","field":"Medicine","cited_by":30,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa; Queen's University; McMaster University","funders":"University of Texas MD Anderson Cancer Center; School of Medicine, Stanford University; Canadian Frailty Network; Ontario Ministry of Economic Development, Job Creation and Trade; Ministero dello Sviluppo Economico; Canada Research Chairs; Natural Sciences and Engineering Research Council of Canada; McMaster University","keywords":"Biology; Mitophagy; Autophagy; Skeletal muscle; Sequestosome 1; Cell biology; FOXO3; Mechanistic target of rapamycin; Muscle atrophy; PINK1; Mitochondrial biogenesis; ULK1; AMP-activated protein kinase; Mitochondrion; PI3K/AKT/mTOR pathway; AMPK; Endocrinology; Protein kinase A; Biochemistry; Protein kinase B; Kinase; Phosphorylation; Signal transduction","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001780023,0.0002821298,0.0003193954,0.0002375093,0.0001783356,0.0002355635,0.0003118469,0.0003321853,0.001117143],"category_scores_gemma":[0.0001034546,0.0002331347,0.0002712004,0.0001586297,0.0003587765,0.000195046,0.0002980994,0.0007058191,0.0003249482],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005626879,"about_ca_system_score_gemma":0.0003058961,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008450751,"about_ca_topic_score_gemma":0.001737822,"domain_scores_codex":[0.9998129,0.00002060701,0.00002241812,0.00005723423,0.00003623161,0.00005062389],"domain_scores_gemma":[0.9998178,0.00002021991,0.00007028279,0.00001671433,0.00001512808,0.00005987905],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003046475,0.00003747391,0.0002005781,0.00004263483,0.00000391199,0.00003110568,0.00001791372,0.00005702363,0.9984834,0.00007000094,0.00004634463,0.0007050877],"study_design_scores_gemma":[0.00004604554,0.0004811635,0.006212017,0.00001013063,0.00002135732,0.0001343626,0.000055975,0.001297319,0.98998,0.00004962715,0.001704115,0.000007755527],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9968635,0.0007787553,0.001065051,0.0001277695,0.00003325149,0.00002169261,0.0004162319,0.00008834869,0.0006054649],"genre_scores_gemma":[0.9947252,0.0004421904,0.001348365,0.00009146844,0.000009909163,0.00007315766,0.0006150856,0.00003771825,0.002656857],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001117143,"threshold_uncertainty_score":0.004082561,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01471213417140936,"score_gpt":0.2720647999009836,"score_spread":0.2573526657295742,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}