{"id":"W4389138908","doi":"10.1080/15548627.2023.2288528","title":"CARM1 drives mitophagy and autophagy flux during fasting-induced skeletal muscle atrophy","year":2023,"lang":"en","type":"article","venue":"Autophagy","topic":"Autophagy in Disease and Therapy","field":"Medicine","cited_by":30,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa; Queen's University; McMaster University","funders":"University of Texas MD Anderson Cancer Center; School of Medicine, Stanford University; Canadian Frailty Network; Ontario Ministry of Economic Development, Job Creation and Trade; Ministero dello Sviluppo Economico; Canada Research Chairs; Natural Sciences and Engineering Research Council of Canada; McMaster University","keywords":"Biology; Mitophagy; Autophagy; Skeletal muscle; Sequestosome 1; Cell biology; FOXO3; Mechanistic target of rapamycin; Muscle atrophy; PINK1; Mitochondrial biogenesis; ULK1; AMP-activated protein kinase; Mitochondrion; PI3K/AKT/mTOR pathway; AMPK; Endocrinology; Protein kinase A; Biochemistry; Protein kinase B; Kinase; Phosphorylation; Signal transduction","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0001931735,0.0005259598,0.0007228004,0.0004565227,0.0005238203,0.00008050899,0.0002456588,0.0002800019,0.000626492],"category_scores_gemma":[0.0001625174,0.0005025237,0.0003316644,0.0008433289,0.0002780905,0.0002599943,0.0002360201,0.000429461,0.0008564901],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001221855,"about_ca_system_score_gemma":0.0002377532,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006924448,"about_ca_topic_score_gemma":0.000006582583,"domain_scores_codex":[0.9968683,0.0001011201,0.0005694862,0.000906422,0.0005717209,0.0009829244],"domain_scores_gemma":[0.9982369,0.0001767348,0.0001663445,0.0007481714,0.0001088303,0.0005630108],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0001918175,0.0003546471,0.002343319,0.0005986845,0.0005676685,0.005327685,0.001835158,0.00003506101,0.9458633,0.001192297,0.001523795,0.04016658],"study_design_scores_gemma":[0.004647259,0.0005698385,0.8010851,0.0001629879,0.000181827,0.0002612984,0.000270722,0.001204492,0.1872065,0.0008104193,0.002994057,0.0006055445],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9921445,0.001674001,0.00002169401,0.0004325336,0.0007564711,0.0005868481,0.0000272367,0.001264469,0.003092222],"genre_scores_gemma":[0.9897006,0.0002621599,0.0002797295,0.0004884486,0.0008799864,0.00009119866,0.00009433167,0.0001369066,0.008066598],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.7987418,"threshold_uncertainty_score":0.9999214,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01471213417140936,"score_gpt":0.2720647999009836,"score_spread":0.2573526657295742,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}