{"id":"W4389149792","doi":"10.20944/preprints202311.1711.v1","title":"Extracellular Signal-Regulated Kinases: One Pathway, Multiple Fates","year":2023,"lang":"en","type":"preprint","venue":"Preprints.org","topic":"Melanoma and MAPK Pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ontario Institute for Cancer Research; Université de Montréal; Montreal Clinical Research Institute","funders":"Canadian Institutes of Health Research","keywords":"MAPK/ERK pathway; Cell biology; Cell fate determination; Kinase; Cell growth; Signal transduction; Context (archaeology); Biology; Extracellular; Transcription factor; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0007033923,0.0006742306,0.0006307297,0.0001612595,0.0001596779,0.00004442354,0.001041886,0.001125122,0.0005397077],"category_scores_gemma":[0.0004291744,0.0007459306,0.0004762161,0.0001491286,0.0001593977,0.000005810682,0.00348664,0.0007229461,0.002168573],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005588407,"about_ca_system_score_gemma":0.0002979825,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003264591,"about_ca_topic_score_gemma":0.0000937177,"domain_scores_codex":[0.9959631,0.000242158,0.0007526363,0.001911511,0.0004190401,0.0007115501],"domain_scores_gemma":[0.9967042,0.00005772051,0.0004156717,0.002285738,0.0002439248,0.0002927037],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001165187,0.0002579245,0.09176645,0.0002636292,0.0003391077,0.00007027521,0.0001329369,0.0008745787,0.9052938,0.00009627639,0.0003122604,0.0004762505],"study_design_scores_gemma":[0.0006682054,0.00009664713,0.05012098,0.0002064298,0.00008530271,0.00001068416,0.0000653289,0.0003396107,0.9250141,0.000911894,0.02162863,0.0008521363],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9934011,0.001485212,0.001046808,0.0001650308,0.0008869545,0.001027735,0.0002482123,0.0003123292,0.001426689],"genre_scores_gemma":[0.9810446,0.0003967844,0.0003545602,0.00005935139,0.0007103937,0.0003607514,0.002454023,0.0001751193,0.01444445],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04164547,"threshold_uncertainty_score":0.9994991,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1253072822317841,"score_gpt":0.3026464343875168,"score_spread":0.1773391521557326,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}