{"id":"W4389149792","doi":"10.20944/preprints202311.1711.v1","title":"Extracellular Signal-Regulated Kinases: One Pathway, Multiple Fates","year":2023,"lang":"en","type":"preprint","venue":"Preprints.org","topic":"Melanoma and MAPK Pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ontario Institute for Cancer Research; Université de Montréal; Montreal Clinical Research Institute","funders":"Canadian Institutes of Health Research","keywords":"MAPK/ERK pathway; Cell biology; Cell fate determination; Kinase; Cell growth; Signal transduction; Context (archaeology); Biology; Extracellular; Transcription factor; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004884625,0.0009708548,0.001442488,0.0009662612,0.0004301428,0.002894056,0.0005267722,0.001168632,0.003382333],"category_scores_gemma":[0.000441176,0.0002325899,0.000543824,0.001157518,0.0008714612,0.002843515,0.001063199,0.002398499,0.002080976],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000619865,"about_ca_system_score_gemma":0.001185377,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002304013,"about_ca_topic_score_gemma":0.0003323456,"domain_scores_codex":[0.9996309,0.00006203179,0.0000398084,0.0000830093,0.000137915,0.00004631147],"domain_scores_gemma":[0.9997925,0.00008075382,0.00002616208,0.00001796585,0.00005282023,0.00002977515],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002993743,0.00009187918,0.0007854063,0.01793653,0.0003055655,0.001331049,0.0006324507,0.0008857888,0.03163736,0.0927567,0.05749623,0.7958416],"study_design_scores_gemma":[0.00001442724,0.00008633195,0.0007364654,0.001911135,0.0001298692,0.002412153,0.0002420034,0.000184483,0.004606312,0.02303206,0.966614,0.00003082105],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"review","genre_gemma":"empirical","genre_scores_codex":[0.002466471,0.9753576,0.00377521,0.003784989,0.002641246,0.00001780915,0.00016766,0.00007849731,0.0117105],"genre_scores_gemma":[0.01456328,0.9707813,0.001774596,0.001771889,0.001919036,0.00003006534,0.0001776734,0.00002963116,0.008952449],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.003382333,"threshold_uncertainty_score":0.01131499,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1253072822317841,"score_gpt":0.3026464343875168,"score_spread":0.1773391521557326,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}