{"id":"W4389161699","doi":"10.1073/pnas.2306788120","title":"Propulsive cell entry diverts pathogens from immune degradation by remodeling the phagocytic synapse","year":2023,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"Toxoplasma gondii Research Studies","field":"Immunology and Microbiology","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of General Medical Sciences; Hospital for Sick Children; Office of Extramural Research, National Institutes of Health; University of Louisville; Arizona State University; National Institutes of Health; National Science Foundation","keywords":"Biology; Cell biology; Phagocytosis; Immune system; Phagocytic Cell; Phagosome; Virulence; Vacuole; Toxoplasma gondii; Immunological synapse; Microbiology; T cell; Immunology; Antibody; Cytoplasm; Biochemistry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001153208,0.0001025824,0.0001569999,0.0001189054,0.0006218253,0.00001789215,0.0008938184,0.0001082049,0.00002438824],"category_scores_gemma":[0.0009290649,0.00005572398,0.00007645986,0.000700413,0.001169646,0.0002396902,0.0004177636,0.0002742119,0.00002918702],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004252974,"about_ca_system_score_gemma":0.00004745142,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004038786,"about_ca_topic_score_gemma":1.544606e-7,"domain_scores_codex":[0.9987981,0.00002866225,0.0002962298,0.0002549636,0.0003773879,0.0002446181],"domain_scores_gemma":[0.998962,0.0004343964,0.0003349431,0.00001369485,0.0002442589,0.00001074942],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002275152,0.00002709442,0.001768506,0.00001924379,0.00004006222,8.347967e-9,0.0005188817,0.0000392853,0.9895185,0.0009021463,0.006769097,0.000374443],"study_design_scores_gemma":[0.0002786088,0.00003567789,0.01626286,0.00005344059,0.00002196676,0.000003145738,0.001336622,0.0003148414,0.973701,0.007371896,0.0005456534,0.00007427618],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9925617,0.001868562,9.472615e-7,0.004031524,0.00005125637,0.000278379,0.0001485757,0.00002512682,0.001033928],"genre_scores_gemma":[0.997828,0.0003788931,0.00007431687,0.00007715262,0.00002197922,0.00002289366,0.000004646525,0.000004117102,0.001588001],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01581747,"threshold_uncertainty_score":0.4782641,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03471837063694651,"score_gpt":0.2875514500247938,"score_spread":0.2528330793878473,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}