{"id":"W4389161922","doi":"10.1039/d3md00441d","title":"A survey of stapling methods to increase affinity, activity, and stability of ghrelin analogues","year":2023,"lang":"en","type":"article","venue":"RSC Medicinal Chemistry","topic":"Regulation of Appetite and Obesity","field":"Neuroscience","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Lawson Health Research Institute; Western University","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research","keywords":"Ghrelin; Growth hormone secretagogue receptor; Chemistry; Receptor; Circular dichroism; Energy homeostasis; Biochemistry; Stereochemistry; Internal medicine; Endocrinology; Biology; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003916915,0.0006879485,0.0003791181,0.0005751259,0.000196306,0.0002274223,0.000342688,0.0003904201,0.001193091],"category_scores_gemma":[0.0004497463,0.0003360108,0.0005768272,0.0005945457,0.0002037645,0.0005062975,0.0002697668,0.0007879475,0.0005393369],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002586234,"about_ca_system_score_gemma":0.0001487759,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003326671,"about_ca_topic_score_gemma":0.0005116253,"domain_scores_codex":[0.9997186,0.00005348648,0.00003167645,0.00005266177,0.00009986721,0.00004368092],"domain_scores_gemma":[0.9998142,0.00005375229,0.00006416481,0.00001215612,0.00003682206,0.00001892379],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003095782,0.0001899085,0.0003724315,0.001621754,0.00007406249,0.0003241312,0.0001217161,0.000996729,0.936729,0.0006327003,0.0006970993,0.05793089],"study_design_scores_gemma":[0.00007412715,0.003801274,0.002961703,0.0001524372,0.0001214499,0.001364407,0.00009146527,0.001242187,0.9289193,0.0002223818,0.06098204,0.00006735465],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7230147,0.245477,0.01867335,0.0006751707,0.0002839206,0.0002732696,0.0006654763,0.0002561926,0.01068099],"genre_scores_gemma":[0.7344623,0.2235177,0.03181011,0.0007022497,0.0001674057,0.0002798513,0.0009707682,0.0001433134,0.007946369],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001193091,"threshold_uncertainty_score":0.003991246,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09053174546567544,"score_gpt":0.3704979261407423,"score_spread":0.2799661806750668,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}