{"id":"W4389166429","doi":"10.21203/rs.3.rs-3661193/v1","title":"A Synthetic Cytotoxic T cell Platform for Rapidly Prototyping TCR Function","year":2023,"lang":"en","type":"preprint","venue":"Research Square","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Cancer Institute; Genome British Columbia; National Institutes of Health; Michael Smith Health Research BC","keywords":"T-cell receptor; Cytotoxic T cell; Major histocompatibility complex; Antigen; Biology; T cell; Granzyme; Computational biology; Cell biology; Human leukocyte antigen; Granzyme B; CD8; Immunology; Immune system; In vitro; Genetics; Perforin","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002924234,0.0003695354,0.0001944537,0.0001584403,0.0001057817,0.0003716794,0.0004594162,0.0003184064,0.001106302],"category_scores_gemma":[0.0003063021,0.0001423292,0.0001870203,0.0001005654,0.000238835,0.0002416248,0.0003942979,0.0004310487,0.0003894381],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002128435,"about_ca_system_score_gemma":0.0001751801,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001342754,"about_ca_topic_score_gemma":0.0001333188,"domain_scores_codex":[0.9997212,0.00004250236,0.00002019202,0.00005479576,0.0001104127,0.00005098197],"domain_scores_gemma":[0.9997936,0.00003575448,0.00006519947,0.00003822005,0.00003054864,0.00003670984],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001893774,0.000007485282,0.00003815996,0.00001677427,0.000001327902,0.00003759318,0.000007717113,0.0003924009,0.9982768,0.0001194036,0.0000182908,0.001065139],"study_design_scores_gemma":[0.000005616211,0.0001500602,0.0001358751,0.000002153284,0.000002858733,0.0001552951,0.000005798336,0.001610316,0.9967533,0.00003505134,0.001139669,0.000004054474],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"methods","genre_scores_codex":[0.9002935,0.0005371005,0.09596566,0.00008444497,0.00007240375,0.0001387038,0.000235043,0.0004682061,0.002204985],"genre_scores_gemma":[0.9437019,0.000371563,0.05296821,0.00004533893,0.00001128626,0.0001063377,0.0002451009,0.00005483605,0.002495403],"genre_candidate":"methods","genre_consensus":null,"teacher_disagreement_score":0.001106302,"threshold_uncertainty_score":0.003700912,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1465617846279784,"score_gpt":0.4190089896662709,"score_spread":0.2724472050382926,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}