{"id":"W4389167211","doi":"10.21203/rs.3.rs-3658114/v1","title":"Forward programming of hiPSCs towards beta-like cells using Ngn3, Pdx1, and MafA","year":2023,"lang":"en","type":"preprint","venue":"Research Square","topic":"Pancreatic function and diabetes","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Horizon 2020 Framework Programme; University of Alberta; Deutsche Forschungsgemeinschaft; University of Galway; European Commission; National University of Ireland","keywords":"PDX1; Induced pluripotent stem cell; Insulin; Biology; Transplantation; Progenitor cell; Stem cell; Beta cell; Endocrinology; Population; Enteroendocrine cell; Internal medicine; Islet; Cell biology; Immunology; Medicine; Hormone; Endocrine system; Embryonic stem cell; Biochemistry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001753808,0.0003045256,0.0002358262,0.0001645466,0.000127762,0.0004487367,0.000201095,0.0001663762,0.001984328],"category_scores_gemma":[0.0001241621,0.00009331592,0.0001992382,0.0001782943,0.000163542,0.0001645056,0.00026731,0.0004352752,0.001007091],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002336363,"about_ca_system_score_gemma":0.0002568768,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007500037,"about_ca_topic_score_gemma":0.0009003403,"domain_scores_codex":[0.9998901,0.000009138126,0.00001202147,0.00002888605,0.00004381738,0.00001599374],"domain_scores_gemma":[0.9999286,0.00001131819,0.00001751985,0.00001331793,0.00001447521,0.00001476058],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003370033,0.00001117006,0.000104983,0.00003600818,0.00000341902,0.00004123982,0.00001451923,0.0001113908,0.9948343,0.0002431256,0.0001918507,0.004374295],"study_design_scores_gemma":[0.000004549364,0.0000222089,0.0006539085,0.000004874643,0.000005426338,0.00007289875,0.000008365368,0.0008203445,0.9913901,0.0000452668,0.006969209,0.000002877068],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.875158,0.002628961,0.09748122,0.0004244699,0.0004378534,0.0002259195,0.003076433,0.002643611,0.01792358],"genre_scores_gemma":[0.902093,0.002225937,0.06189604,0.0002481864,0.00004204093,0.0001684044,0.002601426,0.0008421386,0.02988284],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001984328,"threshold_uncertainty_score":0.006638229,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.179864624722816,"score_gpt":0.4276907141681793,"score_spread":0.2478260894453633,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}