{"id":"W4389180597","doi":"10.17912/micropub.biology.000900","title":"A dominant dpy-10 co-transformation marker using CRISPR/Cas9 and a linear repair template in Caenorhabditis tropicalis","year":2023,"lang":"en","type":"article","venue":"PubMed","topic":"Genetics, Aging, and Longevity in Model Organisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Natural Sciences and Engineering Research Council of Canada; National Institutes of Health; University of Alberta; University of Minnesota","keywords":"CRISPR; Cas9; Caenorhabditis elegans; Genetics; Biology; Mutant; Transformation (genetics); Gene; Genome editing; Mutation; Phenotype; Genetic screen; Computational biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002789693,0.0006726739,0.0005420095,0.0008425203,0.0006993918,0.0003875125,0.001138531,0.0008258959,0.005017102],"category_scores_gemma":[0.0001874784,0.0004865408,0.0005480269,0.0005476745,0.0006019134,0.0003682267,0.0005928859,0.00171972,0.002920032],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001004219,"about_ca_system_score_gemma":0.0008301538,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.006588942,"about_ca_topic_score_gemma":0.01440263,"domain_scores_codex":[0.9995727,0.00002601723,0.00005636871,0.0001644007,0.0001189958,0.00006142509],"domain_scores_gemma":[0.9997597,0.00004252833,0.0000635707,0.00004052018,0.00002388831,0.00006988738],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009435729,0.00003005644,0.00009823731,0.0001114394,0.000006862515,0.0001427613,0.00003295594,0.00005494713,0.9961035,0.0003099397,0.0006677796,0.002347183],"study_design_scores_gemma":[0.0000617696,0.0001324598,0.004121793,0.00003033249,0.00003505226,0.000681157,0.00006930948,0.001240484,0.9659044,0.0001215142,0.02756983,0.00003199508],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7821362,0.005649182,0.1074226,0.001417416,0.001896987,0.001461563,0.05294758,0.01118829,0.03588014],"genre_scores_gemma":[0.8322957,0.001933919,0.07195675,0.0003746389,0.00003534956,0.0006503829,0.02452387,0.00161583,0.06661354],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006588942,"threshold_uncertainty_score":0.01678389,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02386926144453363,"score_gpt":0.2587150715440438,"score_spread":0.2348458100995101,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}