{"id":"W4389192043","doi":"10.22215/etd/2023-15670","title":"Effect of Phosphothioate Modification on the Anti-L-Tyrosinamide Aptamer","year":2023,"lang":"en","type":"dissertation","venue":"","topic":"Advanced biosensing and bioanalysis techniques","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Carleton University","funders":"","keywords":"Aptamer; Chemistry; DNA; Combinatorial chemistry; Selectivity; Computational biology; Flexibility (engineering); RNA; Binding affinities; Small molecule; Biophysics; Nanotechnology; Molecular biology; Biochemistry; Biology; Receptor; Materials science; Gene; Mathematics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00027801,0.0004125103,0.0001804234,0.0001111004,0.00008265922,0.0002295268,0.0001947028,0.0003596687,0.001007085],"category_scores_gemma":[0.000514865,0.0001832111,0.0002108406,0.0001412878,0.0001532947,0.0001799894,0.0001141689,0.0002984437,0.0002822347],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001184477,"about_ca_system_score_gemma":0.0001427361,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005827431,"about_ca_topic_score_gemma":0.0007157489,"domain_scores_codex":[0.9997405,0.00006156485,0.00002519103,0.00007122005,0.00006495762,0.00003661021],"domain_scores_gemma":[0.9997159,0.0001373882,0.00006010912,0.0000185795,0.00004750182,0.00002050167],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009328607,0.00001655943,0.00007897095,0.0000319003,0.000006609149,0.00003121038,0.00001259978,0.0000876859,0.9985494,0.00001021792,0.00001070539,0.00107074],"study_design_scores_gemma":[0.000001913557,0.0001582217,0.000418396,0.000001125598,0.000006824335,0.00002815636,0.000003269874,0.0002163913,0.9989298,0.000002536911,0.0002317074,0.000001630265],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9943537,0.0008421522,0.003005894,0.00004484985,0.00003584971,0.00003707041,0.00008989919,0.00004177333,0.001548891],"genre_scores_gemma":[0.9919817,0.0006446023,0.004731707,0.00008437815,0.00001178222,0.00002418321,0.0001141697,0.00002730143,0.002380102],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001007085,"threshold_uncertainty_score":0.003369033,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01018950629081914,"score_gpt":0.3067338520528959,"score_spread":0.2965443457620768,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}