{"id":"W4389194993","doi":"10.1016/j.jbc.2023.105520","title":"Structure of methyltransferase RedM that forms the dimethylpyrrolinium of the bisindole reductasporine","year":2023,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Biochemical and Molecular Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia Hospital; University of British Columbia","funders":"Natural Sciences and Engineering Research Council of Canada; University of British Columbia; Michael Smith Health Research BC","keywords":"Mutagenesis; Chemistry; Enzyme; Active site; Stereochemistry; Biochemistry; Common core; Combinatorial chemistry; Gene; Mutation; Core (optical fiber); Materials science","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004732866,0.0001527185,0.0002894383,0.00002162679,0.0000541448,0.000007205158,0.0007757221,0.0003079429,0.00005425437],"category_scores_gemma":[0.0004830023,0.00006651942,0.0004159812,0.0003071197,0.0004998767,0.000003113306,0.0002496569,0.0004086792,5.152781e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000008789979,"about_ca_system_score_gemma":0.0001063394,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000003574448,"about_ca_topic_score_gemma":5.033917e-7,"domain_scores_codex":[0.9986863,0.00008774898,0.0004549112,0.0001832557,0.0003436576,0.0002441817],"domain_scores_gemma":[0.9989043,0.00006053075,0.0003225308,0.0004025577,0.0002191808,0.00009083641],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002759758,0.00005121786,0.001104334,0.00005427904,0.000100647,0.000004763288,0.00001728623,0.00001855382,0.997047,0.00001104791,0.0007745409,0.0005403723],"study_design_scores_gemma":[0.0004353128,0.0001890569,0.002806155,0.00002995082,0.00002495109,0.00007931918,0.0001259433,0.000002726916,0.9928214,0.0005685454,0.002831677,0.00008498606],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.997399,0.001176779,0.00005028271,0.0009187757,0.00008906232,0.00009709628,0.00006697267,0.000003551751,0.0001984271],"genre_scores_gemma":[0.9987743,0.0006435906,0.00009480743,0.00008143057,0.0002019667,0.000001595575,0.00003047472,0.00001063583,0.0001611426],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004225605,"threshold_uncertainty_score":0.2712583,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02672149379112986,"score_gpt":0.2871568891393258,"score_spread":0.2604353953481959,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}