{"id":"W4389204677","doi":"10.3389/fcell.2023.1256998","title":"Role of epigenetics and the transcription factor Sp1 in the expression of the D prostanoid receptor 1 in human cartilage","year":2023,"lang":"en","type":"article","venue":"Frontiers in Cell and Developmental Biology","topic":"Inflammatory mediators and NSAID effects","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université du Québec à Trois-Rivières; Hôpital du Sacré-Cœur de Montréal; Université de Montréal","funders":"Canadian Institutes of Health Research; Arthritis Society","keywords":"DNA methylation; Epigenetics; Transcription factor; Sp1 transcription factor; Chromatin immunoprecipitation; Promoter; Biology; Methylation; Pioneer factor; Regulation of gene expression; Epigenetics of physical exercise; Molecular biology; Cell biology; Gene expression; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000255729,0.0002371731,0.0003010345,0.0004382688,0.0001963234,0.0003342203,0.0002120616,0.0002886659,0.001045307],"category_scores_gemma":[0.0003309317,0.0002149256,0.0002622376,0.0001845087,0.0003588556,0.000172343,0.0002482649,0.0003452703,0.0003116537],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002576569,"about_ca_system_score_gemma":0.0002150634,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009600661,"about_ca_topic_score_gemma":0.000724785,"domain_scores_codex":[0.9997358,0.00004131846,0.00001887873,0.00009819073,0.0000699211,0.00003586295],"domain_scores_gemma":[0.9998156,0.00003065798,0.00006522386,0.00002124815,0.0000362077,0.00003099541],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002600595,0.00002360403,0.004561506,0.0001096035,0.00002066723,0.0001930975,0.0001526388,0.00009185432,0.9856328,0.0002549928,0.00006872908,0.008630546],"study_design_scores_gemma":[0.00007771794,0.0007718682,0.305836,0.00007906507,0.0001607266,0.002377238,0.0004934793,0.002410923,0.6792244,0.0007583717,0.007764186,0.00004597593],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.974551,0.01826638,0.004778058,0.0002988343,0.00005827528,0.00003257768,0.0004417095,0.00006423512,0.001508967],"genre_scores_gemma":[0.9949569,0.002250473,0.001180389,0.00006897347,0.00002285417,0.00001821237,0.0002275412,0.000008893665,0.001265808],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001045307,"threshold_uncertainty_score":0.003496945,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007532499325973415,"score_gpt":0.2175336081610315,"score_spread":0.2100011088350581,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}