{"id":"W4389205919","doi":"10.1021/acsmedchemlett.3c00386","title":"Development of HC-258, a Covalent Acrylamide TEAD Inhibitor That Reduces Gene Expression and Cell Migration","year":2023,"lang":"en","type":"article","venue":"ACS Medicinal Chemistry Letters","topic":"Hippo pathway signaling and YAP/TAZ","field":"Biochemistry, Genetics and Molecular Biology","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ontario Institute for Cancer Research; University of Toronto; Structural Genomics Consortium; Université du Québec à Montréal","funders":"Natural Sciences and Engineering Research Council of Canada; Structural Genomics Consortium; Agence Nationale de la Recherche; Université du Québec à Montréal","keywords":"CYR61; CTGF; Hippo signaling pathway; Chemistry; Transcription factor; Cysteine; Covalent bond; Cell growth; Cell biology; Cancer research; Biochemistry; Gene; Biology; Growth factor; Receptor; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001078761,0.0002413285,0.0001768244,0.0001616708,0.0001019762,0.0001375238,0.0002355943,0.000273313,0.001022594],"category_scores_gemma":[0.00007282704,0.0001273637,0.0001844302,0.00007068307,0.0001187286,0.0001291668,0.0001143575,0.0004926151,0.000269342],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001961705,"about_ca_system_score_gemma":0.0002220877,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005309588,"about_ca_topic_score_gemma":0.0008246836,"domain_scores_codex":[0.9999439,0.00000508466,0.000004691554,0.00001404691,0.00001982357,0.00001257952],"domain_scores_gemma":[0.9999505,0.000004088703,0.00001505412,0.00000633223,0.000007404397,0.00001663445],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007207286,0.00006242564,0.0000600278,0.00003605281,0.000006446504,0.00006066783,0.000007332268,0.0001080121,0.9961445,0.000115996,0.0001004137,0.003226017],"study_design_scores_gemma":[0.00005299849,0.0007726536,0.0006666689,0.000003644616,0.00001369996,0.0002121566,0.000004898403,0.0003837551,0.9933079,0.00001863148,0.004559159,0.000003719056],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9813645,0.00370621,0.007482909,0.0003761911,0.00008302164,0.000191895,0.0006200486,0.0002177815,0.005957333],"genre_scores_gemma":[0.9843116,0.002320341,0.007281558,0.00010313,0.00001579706,0.00008187363,0.0008298304,0.00001948373,0.005036357],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001022594,"threshold_uncertainty_score":0.003420949,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01545797353758698,"score_gpt":0.234016183135927,"score_spread":0.21855820959834,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}