{"id":"W4389205919","doi":"10.1021/acsmedchemlett.3c00386","title":"Development of HC-258, a Covalent Acrylamide TEAD Inhibitor That Reduces Gene Expression and Cell Migration","year":2023,"lang":"en","type":"article","venue":"ACS Medicinal Chemistry Letters","topic":"Hippo pathway signaling and YAP/TAZ","field":"Biochemistry, Genetics and Molecular Biology","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ontario Institute for Cancer Research; University of Toronto; Structural Genomics Consortium; Université du Québec à Montréal","funders":"Natural Sciences and Engineering Research Council of Canada; Structural Genomics Consortium; Agence Nationale de la Recherche; Université du Québec à Montréal","keywords":"CYR61; CTGF; Hippo signaling pathway; Chemistry; Transcription factor; Cysteine; Covalent bond; Cell growth; Cell biology; Cancer research; Biochemistry; Gene; Biology; Growth factor; Receptor; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002860593,0.0001753174,0.0001637891,0.00003231343,0.00008979299,0.00001064051,0.0001348835,0.0001331857,0.000007548282],"category_scores_gemma":[0.00004273987,0.0001568815,0.0000419214,0.00008844079,0.0001078325,0.000004438516,0.00009095464,0.0001064826,0.000004528367],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001753667,"about_ca_system_score_gemma":0.00007928375,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000006148884,"about_ca_topic_score_gemma":0.000001709829,"domain_scores_codex":[0.9988316,0.0000232396,0.0002799705,0.0003495964,0.000282852,0.0002328006],"domain_scores_gemma":[0.9994912,0.00001803203,0.0001449932,0.0002020665,0.00003874709,0.0001050221],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005999038,0.00002574714,0.0004476896,0.0001540868,0.00001873722,0.00001277632,0.0007452996,0.00002246423,0.9962147,4.690282e-8,0.001557307,0.0007411391],"study_design_scores_gemma":[0.0004730012,0.00002876694,0.0003133533,0.0001317986,0.00001728376,0.00001319821,0.0006245662,0.000008660856,0.9938995,0.00000155917,0.004319435,0.0001688938],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9986132,0.0004072528,0.0001651706,0.000508911,0.00009303797,0.0000866145,0.00001067303,0.00002607563,0.00008909932],"genre_scores_gemma":[0.9971576,0.0001435039,0.001587802,0.0002029413,0.0003044321,0.00002289819,0.0003231856,0.00001922888,0.0002384199],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002762128,"threshold_uncertainty_score":0.6397443,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01545797353758698,"score_gpt":0.234016183135927,"score_spread":0.21855820959834,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}