{"id":"W4389218846","doi":"10.1182/blood-2023-187455","title":"The Challenge of Treating Relapsed Myeloid Leukemia in Children with Down Syndrome - a Targeted Analysis Using Patient-Derived Xenograft Models","year":2023,"lang":"en","type":"article","venue":"Blood","topic":"Acute Myeloid Leukemia Research","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children","funders":"","keywords":"Medicine; Decitabine; Cytarabine; Context (archaeology); Myeloid leukemia; Venetoclax; Oncology; Down syndrome; Internal medicine; Transplantation; Leukemia; Hematopoietic stem cell transplantation; Myelopoiesis; Myeloid; GATA1; Immunology; Stem cell; Haematopoiesis; Erythropoiesis; Biology; Anemia; DNA methylation","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001085455,0.0005022218,0.0005173405,0.0003520846,0.0002057277,0.001069848,0.000625758,0.0006355694,0.001857338],"category_scores_gemma":[0.0004712067,0.0002097495,0.0004988591,0.0001654727,0.0003022838,0.000606121,0.0004067634,0.002934556,0.0007021992],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005214509,"about_ca_system_score_gemma":0.0005380833,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005897754,"about_ca_topic_score_gemma":0.0009662829,"domain_scores_codex":[0.9995812,0.0001392269,0.00002820548,0.00004825395,0.0001519506,0.00005125293],"domain_scores_gemma":[0.9996829,0.00009144238,0.00005378035,0.00006021133,0.0000451153,0.00006650767],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001154057,0.001079326,0.004127866,0.0007876851,0.0002243021,0.0008173303,0.0002780045,0.004366118,0.9309909,0.009419713,0.008396788,0.03835788],"study_design_scores_gemma":[0.0008761458,0.01320936,0.01369258,0.0004096763,0.0007291223,0.01072103,0.0006596897,0.01487147,0.7687716,0.003052573,0.1729287,0.00007804616],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8993542,0.04222742,0.0304307,0.005484005,0.00105569,0.0004994057,0.007120021,0.000589066,0.01323951],"genre_scores_gemma":[0.9577233,0.01897812,0.01318953,0.000742012,0.00008090196,0.0005746385,0.004441191,0.00008116441,0.004189127],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001857338,"threshold_uncertainty_score":0.006213427,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01876873671367195,"score_gpt":0.2578453370201008,"score_spread":0.2390766003064289,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}