{"id":"W4389218958","doi":"10.1016/j.tranon.2023.101846","title":"Biological landscape and nanostructural view in development and reversal of oxaliplatin resistance in colorectal cancer","year":2023,"lang":"en","type":"review","venue":"Translational Oncology","topic":"Cancer Mechanisms and Therapy","field":"Medicine","cited_by":28,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"","keywords":"Colorectal cancer; Oxaliplatin; Cancer research; Metastasis; Chemotherapy; Autophagy; Apoptosis; Cancer; Drug resistance; Cancer cell; Medicine; Cell cycle; Biology; Internal medicine; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002568165,0.0001781423,0.00127083,0.0001960378,0.00001680772,0.000002338827,0.00004057393,0.0003187113,0.00009586001],"category_scores_gemma":[0.00001428645,0.0001344507,0.00005684858,0.0002692938,0.00007898937,0.00001804519,0.00001384689,0.0002454997,0.000001097843],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001126456,"about_ca_system_score_gemma":0.0007677905,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003191083,"about_ca_topic_score_gemma":0.003670079,"domain_scores_codex":[0.998777,0.00009684176,0.0005842528,0.0002770401,0.0001093504,0.0001554914],"domain_scores_gemma":[0.9994505,0.0002948911,0.0001439385,0.0000415697,0.00002253477,0.00004657115],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.000687012,0.00006033729,0.002413365,0.007750588,0.0001523668,0.0001059401,0.001050797,0.000001112172,0.00008211089,0.003412445,0.00002938126,0.9842545],"study_design_scores_gemma":[0.003424985,0.0003216706,0.04999329,0.009992639,0.0001419227,0.00006256059,0.0000334728,0.000009707823,0.00001436695,0.001053416,0.934653,0.0002989708],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.03127735,0.9674699,0.000002171672,0.0002483797,0.0001026464,0.0006392249,0.00006042613,0.000009528605,0.0001904017],"genre_scores_gemma":[0.003533997,0.9945488,0.001515193,0.00004053424,0.0000505789,0.0001320201,0.0001132667,0.00001652823,0.00004907753],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9839556,"threshold_uncertainty_score":0.5482742,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09829512700033903,"score_gpt":0.396018935139299,"score_spread":0.29772380813896,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}