{"id":"W4389219114","doi":"10.1136/jitc-2023-007631","title":"Enhanced CD1d phosphatidylserine presentation using a single-domain antibody promotes immunomodulatory CD1d-TIM-3 interactions","year":2023,"lang":"en","type":"article","venue":"Journal for ImmunoTherapy of Cancer","topic":"Phagocytosis and Immune Regulation","field":"Immunology and Microbiology","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity","funders":"LAVA Therapeutics; Medical Research Council; National Health and Medical Research Council; Vrije Universiteit Amsterdam","keywords":"CD1D; Antigen presentation; Cell biology; Phosphatidylserine; Biology; Antibody; Immune system; Chemistry; T cell; Immunology; Biochemistry; T-cell receptor; Phospholipid","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009585228,0.0002249777,0.0001585529,0.0001106964,0.00009593943,0.0002302117,0.0001501438,0.0002262693,0.002157231],"category_scores_gemma":[0.00008929909,0.00006263734,0.0001856115,0.00007575024,0.0001281915,0.0001249217,0.0002119399,0.0004336906,0.0004992592],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000309068,"about_ca_system_score_gemma":0.0001496827,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001376292,"about_ca_topic_score_gemma":0.0002081721,"domain_scores_codex":[0.9999096,0.0000103492,0.000005601518,0.00001871971,0.00001977061,0.00003584276],"domain_scores_gemma":[0.9999394,0.000008954148,0.00001606843,0.000004902124,0.000006683566,0.00002397086],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000110438,0.00003883018,0.0001928453,0.00003833876,0.000005070869,0.00003132839,0.000007395626,0.000077367,0.9983013,0.00008067828,0.00007235652,0.001043945],"study_design_scores_gemma":[0.00002693867,0.0001854761,0.001423981,0.000004447519,0.00001169887,0.0001369178,0.00001181289,0.0009603968,0.99545,0.00002569484,0.001760482,0.000002163979],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9960828,0.0005042324,0.002036921,0.00009938262,0.00002369923,0.00002071526,0.0001368075,0.00004399009,0.001051497],"genre_scores_gemma":[0.9972392,0.0001983547,0.001304306,0.00005282817,0.000005846924,0.0000168896,0.000155573,0.000008791983,0.001018176],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002157231,"threshold_uncertainty_score":0.007216692,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03603972794639646,"score_gpt":0.3680940057745634,"score_spread":0.3320542778281669,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}