{"id":"W4389219681","doi":"10.1182/blood-2023-190058","title":"A First-in-Human, Open-Label, Phase I Dose Escalation Trial of Daily Oral Nmt Inhibitor Zelenirstat in Patients with Relapsed/Refractory B-Cell Lymphomas and Advanced Solid Tumors","year":2023,"lang":"en","type":"article","venue":"Blood","topic":"Peptidase Inhibition and Analysis","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta; Princess Margaret Cancer Centre; Spinal Cord Injury BC; University of British Columbia; University Health Network; Centre Hospitalier de l’Université de Montréal","funders":"","keywords":"Neutropenia; Tolerability; Medicine; Pharmacology; Febrile neutropenia; Pharmacokinetics; Internal medicine; Cancer; Refractory (planetary science); Toxicity; Oncology; Gastroenterology; Adverse effect; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001594479,0.002104183,0.002418844,0.0006168393,0.0006724044,0.001226526,0.001173623,0.001243364,0.003773465],"category_scores_gemma":[0.0008173796,0.0008255026,0.001096463,0.0004755289,0.001369154,0.001541374,0.0005096299,0.003630993,0.001108184],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001310457,"about_ca_system_score_gemma":0.001736695,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009267437,"about_ca_topic_score_gemma":0.002504977,"domain_scores_codex":[0.9994847,0.0001816502,0.00002579733,0.0001198066,0.00003793916,0.0001501715],"domain_scores_gemma":[0.9992632,0.00008941128,0.000106375,0.00007803844,0.00004732769,0.0004156943],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.7425892,0.1048437,0.006498342,0.0006774508,0.0009315997,0.0003848482,0.0004649533,0.003477925,0.06647293,0.0004049294,0.004807329,0.06844674],"study_design_scores_gemma":[0.502719,0.4771821,0.008329338,0.00001977667,0.0003141248,0.0002990912,0.00008597806,0.001843844,0.00601502,0.0003493497,0.002806274,0.00003604892],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9894884,0.001002036,0.0007961881,0.0003936233,0.0001136487,0.004788756,0.001394112,0.0001836493,0.00183952],"genre_scores_gemma":[0.9874707,0.000742477,0.002025872,0.0006674437,0.0001574309,0.004157214,0.00219763,0.00005222506,0.00252905],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003773465,"threshold_uncertainty_score":0.01262343,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01822706120611121,"score_gpt":0.2967600566122108,"score_spread":0.2785329954060996,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}