{"id":"W4389219761","doi":"10.1182/blood-2023-173949","title":"Dexamethasone is Associated with a Lower Incidence and Severity of Cytokine Release Syndrome Compared with Other Corticosteroid Regimens When Given as Premedication for Glofitamab Monotherapy in Patients with Relapsed/Refractory (R/R) Large B-Cell Lymphoma (LBCL)","year":2023,"lang":"en","type":"article","venue":"Blood","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"Roche (Canada)","funders":"","keywords":"Medicine; Premedication; Cytokine release syndrome; Prednisolone; Dexamethasone; Corticosteroid; Internal medicine; Methylprednisolone; Prednisone; Follicular lymphoma; Gastroenterology; Surgery; Lymphoma; Cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004788114,0.0001806138,0.0005066849,0.0001195831,0.0001126041,0.000371263,0.0001736353,0.0002163329,0.0009439462],"category_scores_gemma":[0.001209954,0.00007079978,0.0003239904,0.0001843525,0.0001504885,0.0002593649,0.000176729,0.0006906007,0.0001594304],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003105572,"about_ca_system_score_gemma":0.0003742893,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002511198,"about_ca_topic_score_gemma":0.000966688,"domain_scores_codex":[0.9996841,0.0001208753,0.00003628524,0.00005396955,0.00006996064,0.00003485363],"domain_scores_gemma":[0.999168,0.0001892113,0.0003551592,0.00005177306,0.00004281634,0.0001930755],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"observational","study_design_scores_codex":[0.1941592,0.005527013,0.2150153,0.001027739,0.001738719,0.001261672,0.000535619,0.002359759,0.1580595,0.0001782232,0.003044483,0.4170927],"study_design_scores_gemma":[0.01726309,0.3178701,0.6086298,0.0001720975,0.001319672,0.005554695,0.0004723062,0.003196727,0.03259652,0.0001962385,0.01267003,0.00005870503],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9960239,0.002602452,0.0002158353,0.00013339,0.00002985544,0.00008430021,0.0001957405,0.0000222752,0.0006923157],"genre_scores_gemma":[0.9990326,0.0003710711,0.0001608509,0.00008410386,0.00001848495,0.00002603831,0.0001525014,0.000002594856,0.0001518311],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009439462,"threshold_uncertainty_score":0.003157854,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01344038479975685,"score_gpt":0.2531730764839318,"score_spread":0.2397326916841749,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}