{"id":"W4389220704","doi":"10.1182/blood-2023-185951","title":"Real World Experience of FLT3-Inhibitor Post-Transplant Maintenance with Sorafenib Demonstrating Superior Overall- and Relapse Free Survival Following Allogeneic Hematopoietic Stem Cell Transplantation in FLT3-ITD Mutated Acute Myeloid Leukemia","year":2023,"lang":"en","type":"article","venue":"Blood","topic":"Acute Myeloid Leukemia Research","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University Health Network","funders":"","keywords":"Sorafenib; Medicine; Oncology; Internal medicine; Tolerability; Transplantation; Clinical endpoint; Maintenance therapy; Hematopoietic stem cell transplantation; Fms-Like Tyrosine Kinase 3; Clinical trial; Adverse effect; Chemotherapy; Hepatocellular carcinoma; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006230206,0.0001543541,0.0002627534,0.0002294039,0.0003391835,0.000370672,0.0002155456,0.0002204932,0.0007773286],"category_scores_gemma":[0.001466154,0.0001164029,0.0002920347,0.0002901968,0.00035319,0.0002318548,0.0003576067,0.0002873841,0.0001726318],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004142089,"about_ca_system_score_gemma":0.0003195766,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007040671,"about_ca_topic_score_gemma":0.0007809633,"domain_scores_codex":[0.9995847,0.0001555565,0.00005199503,0.00009052015,0.00005787182,0.00005933326],"domain_scores_gemma":[0.9989114,0.0002536235,0.0004961746,0.00009516509,0.00006663741,0.0001770005],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.004052744,0.001041301,0.9586985,0.00009117583,0.0001145534,0.006622053,0.0007798914,0.0006320021,0.00435581,0.0001320879,0.000402124,0.0230777],"study_design_scores_gemma":[0.0003674047,0.01367908,0.9488478,0.0000332805,0.00019487,0.02583032,0.0008058462,0.001441618,0.005011046,0.0001627762,0.00356586,0.00006016799],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9994178,0.0001823538,0.0001401177,0.00001884147,0.000003207357,0.00001070285,0.00007899472,0.000001938941,0.0001460225],"genre_scores_gemma":[0.9996206,0.00008652676,0.00009282754,0.00001714564,0.000009030623,0.000005363444,0.0001212886,0.000001103061,0.00004608963],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007773286,"threshold_uncertainty_score":0.003294885,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01152315932758995,"score_gpt":0.2510350328995918,"score_spread":0.2395118735720018,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}