{"id":"W4389220823","doi":"10.1182/blood-2023-187244","title":"DNMT3A R882H Exhibits Greater Inflammatory Potential Than R882C in Primary Hematopoietic Stem and Progenitor Cell Knock-in Model and Population Data","year":2023,"lang":"en","type":"article","venue":"Blood","topic":"Acute Myeloid Leukemia Research","field":"Medicine","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University","funders":"","keywords":"Biology; Transcriptome; Progenitor cell; Haematopoiesis; Population; Gene expression profiling; Stem cell; Genetics; Molecular biology; Gene; Gene expression","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000374042,0.0003380282,0.0004738821,0.0004187356,0.0002127853,0.0003567048,0.0002373171,0.0003160359,0.002459195],"category_scores_gemma":[0.000210522,0.0001740629,0.0004008393,0.0003230522,0.0002673869,0.0001460931,0.0002892171,0.0009647315,0.000560081],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000249604,"about_ca_system_score_gemma":0.0002201817,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001218548,"about_ca_topic_score_gemma":0.001958441,"domain_scores_codex":[0.9995649,0.00005001836,0.00005922779,0.0001101849,0.0001578293,0.00005776987],"domain_scores_gemma":[0.9997384,0.00006300521,0.00006577511,0.0000482864,0.00003192766,0.00005254627],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007458741,0.00002379952,0.0002357072,0.00003109953,0.000008541548,0.0000349899,0.00001585805,0.0001411559,0.9985602,0.00005859079,0.00005499394,0.0007604313],"study_design_scores_gemma":[0.00001481941,0.0002357936,0.004443849,0.000007027657,0.00003433659,0.0002097184,0.00003302092,0.001301957,0.9909609,0.00005637312,0.002694174,0.000007957517],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9674344,0.0005687573,0.02168199,0.0001584822,0.00004076767,0.0001298716,0.007416147,0.000531316,0.002038382],"genre_scores_gemma":[0.96334,0.0008499778,0.02115072,0.0001784323,0.00001135156,0.0004460277,0.007678749,0.0002584047,0.006086333],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002459195,"threshold_uncertainty_score":0.008226812,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02903437628249744,"score_gpt":0.2654324607623855,"score_spread":0.236398084479888,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}