{"id":"W4389220841","doi":"10.1182/blood-2023-174929","title":"A Phase I/II Trial to Evaluate the Safety, Pharmacokinetics, and Efficacy of Glofitamab As Monotherapy and in Combination with R-ICE Chemoimmunotherapy in Children and Young Adults with Relapsed/Refractory B-Cell Non-Hodgkin Lymphoma (iMATRIX-GLO)","year":2023,"lang":"en","type":"article","venue":"Blood","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Roche (Canada)","funders":"","keywords":"Chemoimmunotherapy; Medicine; Tumor lysis syndrome; Neutropenia; Internal medicine; Population; Febrile neutropenia; Rituximab; Cytokine release syndrome; Oncology; Tolerability; Lymphoma; Gastroenterology; Cancer; Adverse effect; Chemotherapy; Immunotherapy; Chimeric antigen receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001415483,0.001218131,0.001672847,0.000312572,0.0003139814,0.00101198,0.0007481477,0.001479229,0.005612692],"category_scores_gemma":[0.001055459,0.0004994127,0.001296959,0.0002990442,0.00099607,0.001131663,0.0004394488,0.003297886,0.001537552],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001061879,"about_ca_system_score_gemma":0.001250452,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006977395,"about_ca_topic_score_gemma":0.00137501,"domain_scores_codex":[0.9996228,0.0001504695,0.00001743101,0.00008635129,0.00003085025,0.00009211898],"domain_scores_gemma":[0.9989026,0.0001367861,0.0002005485,0.0001006184,0.0000683529,0.0005911078],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.8362275,0.05909317,0.00714192,0.0007244945,0.001482554,0.0002828093,0.0003315812,0.001364838,0.01710993,0.0004696155,0.00476962,0.07100194],"study_design_scores_gemma":[0.625581,0.3612734,0.007097493,0.00004638108,0.0003818494,0.0003594785,0.00007137172,0.0007111776,0.001135067,0.0003595186,0.002959516,0.00002370629],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9883893,0.002733275,0.0005578258,0.0008100211,0.000219567,0.003263643,0.001902465,0.0001034871,0.002020479],"genre_scores_gemma":[0.9803068,0.00201734,0.002466799,0.002082273,0.0002288595,0.005714944,0.003457624,0.00003964455,0.003685721],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005612692,"threshold_uncertainty_score":0.01877636,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01065949386111554,"score_gpt":0.3034972203528816,"score_spread":0.292837726491766,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}