{"id":"W4389221075","doi":"10.1182/blood-2023-182116","title":"Durable Clinical Benefits of Idasanutlin Therapy in Hydroxyurea-Refractory Polycythemia Vera","year":2023,"lang":"en","type":"article","venue":"Blood","topic":"Myeloproliferative Neoplasms: Diagnosis and Treatment","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University Health Network","funders":"","keywords":"Phlebotomy; Medicine; Discontinuation; Clinical trial; Internal medicine; Polycythemia vera; Refractory (planetary science); Thrombocytosis; Surgery; Platelet","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001642028,0.0001424328,0.0005195849,0.0002870516,0.0001669263,0.0004063489,0.0001487841,0.0001613064,0.0006261945],"category_scores_gemma":[0.00173657,0.00005076066,0.0001986915,0.0003188669,0.0002129856,0.0002303081,0.0001951768,0.0005230774,0.0000854131],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000287862,"about_ca_system_score_gemma":0.0002486539,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001798055,"about_ca_topic_score_gemma":0.0005320632,"domain_scores_codex":[0.9995315,0.000175798,0.00008146896,0.00005599114,0.0001044737,0.00005077997],"domain_scores_gemma":[0.9984326,0.0006288459,0.0005444821,0.00008022247,0.00008808194,0.0002256797],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.03234047,0.002670477,0.4633376,0.0008168462,0.0007006751,0.001114876,0.0003563126,0.001110798,0.04828426,0.0002560998,0.002239033,0.4467728],"study_design_scores_gemma":[0.003823569,0.09507636,0.8774149,0.0001530088,0.0006137918,0.003618353,0.0001417995,0.001915865,0.009412573,0.000209074,0.007590521,0.00003003392],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9913121,0.006344514,0.0004829548,0.0001412289,0.00002835309,0.0001303138,0.0003074901,0.00002021147,0.001232786],"genre_scores_gemma":[0.9978416,0.0009879756,0.0003278962,0.0001595042,0.0000663934,0.00004209875,0.0004076261,0.000002471365,0.0001645303],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001642028,"threshold_uncertainty_score":0.00868398,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04865075982292039,"score_gpt":0.3313921430104009,"score_spread":0.2827413831874805,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}