{"id":"W4389221450","doi":"10.1182/blood-2023-173991","title":"Safety, Pharmacodynamic, and Anti-Tumor Activity of SL-172154 As Monotherapy and in Combination with Azacitidine (AZA) in Relapsed/Refractory (R/R) Acute Myeloid Leukemia (AML) and Higher-Risk Myelodysplastic Syndromes/Neoplasms (HR-MDS) Patients (pts)","year":2023,"lang":"en","type":"article","venue":"Blood","topic":"Phagocytosis and Immune Regulation","field":"Immunology and Microbiology","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre","funders":"","keywords":"Medicine; Pharmacodynamics; Azacitidine; Myelodysplastic syndromes; Internal medicine; Lenalidomide; Oncology; Neutropenia; Gemtuzumab ozogamicin; Pharmacology; Pharmacokinetics; Toxicity; CD33; Bone marrow; Stem cell; CD34; Multiple myeloma; Chemistry; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007010959,0.0004256995,0.000937198,0.0004011285,0.0001699732,0.0004819397,0.0003561487,0.0004877844,0.001398853],"category_scores_gemma":[0.0006141933,0.0002268274,0.0005971125,0.0003169037,0.0003848758,0.0003726118,0.0001894156,0.00111214,0.0004298374],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004935697,"about_ca_system_score_gemma":0.0004728001,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003758891,"about_ca_topic_score_gemma":0.0008200778,"domain_scores_codex":[0.9996735,0.0001559549,0.00002502451,0.00005341892,0.00004741309,0.00004467653],"domain_scores_gemma":[0.9994992,0.00009051448,0.0001466409,0.00004374382,0.00004099425,0.0001788429],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.4466445,0.03820292,0.0501956,0.0006671702,0.001001151,0.0005903451,0.0005081368,0.005096787,0.276155,0.0002732352,0.001799201,0.1788658],"study_design_scores_gemma":[0.03700285,0.7971941,0.1025317,0.00004455634,0.001008971,0.001022012,0.0001530836,0.002081467,0.054784,0.0001809038,0.003939881,0.00005652558],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9983853,0.0008619941,0.00008439949,0.00005782035,0.00001046354,0.00009725186,0.0001727582,0.00001492712,0.0003150699],"genre_scores_gemma":[0.9978531,0.0005203355,0.0002702303,0.00009031114,0.00003146982,0.0001237278,0.0005152292,0.000006184024,0.0005893054],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001398853,"threshold_uncertainty_score":0.00467968,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006290228415833346,"score_gpt":0.2225909775030456,"score_spread":0.2163007490872122,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}