{"id":"W4389221849","doi":"10.1182/blood-2023-187251","title":"A Randomized Comparison of Liposomal Daunorubicin/Daunorubicin Combined with Low-Dose Cytarabine and Etoposide or High-Dose Cytarabine and Fludarabine in Induction Treatment of Pediatric AML Using MRD-Based Risk Stratification in the NOPHO-DBH AML 2012 Protocol","year":2023,"lang":"en","type":"article","venue":"Blood","topic":"Acute Myeloid Leukemia Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; University Health Network","funders":"","keywords":"Cytarabine; Medicine; Fludarabine; Etoposide; Daunorubicin; Internal medicine; Randomization; Minimal residual disease; Mitoxantrone; Population; Oncology; Transplantation; Induction chemotherapy; Randomized controlled trial; Leukemia; Gastroenterology; Surgery; Chemotherapy; Cyclophosphamide","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003723203,0.002307552,0.003132686,0.0005190413,0.0005724631,0.001288935,0.00157371,0.002031401,0.006940406],"category_scores_gemma":[0.003574965,0.0009018775,0.002039426,0.0004152101,0.001742339,0.0009848248,0.0008844964,0.002922359,0.0009393516],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001741158,"about_ca_system_score_gemma":0.003089671,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001657398,"about_ca_topic_score_gemma":0.002846972,"domain_scores_codex":[0.9978024,0.001402758,0.0001612168,0.0002934002,0.000130128,0.0002100415],"domain_scores_gemma":[0.9979324,0.0005591135,0.0005387012,0.000175763,0.0001697054,0.000624326],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9892361,0.005152298,0.0001950768,0.0002307259,0.0004261345,0.0000128918,0.00002401435,0.0002080929,0.00107672,0.00007481978,0.0002334385,0.003129742],"study_design_scores_gemma":[0.9514832,0.04654875,0.000562883,0.00002188914,0.0003616973,0.00001015714,0.00001028978,0.000237118,0.0002863645,0.0001109599,0.0003574928,0.000009208103],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9543695,0.001423387,0.001295429,0.000834983,0.0006904724,0.03738729,0.001717703,0.00009481785,0.002186573],"genre_scores_gemma":[0.9469755,0.001485063,0.004371128,0.001544782,0.0005416697,0.03984705,0.001558349,0.00003406332,0.003642475],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006940406,"threshold_uncertainty_score":0.02321792,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03754446356356207,"score_gpt":0.3335372662799392,"score_spread":0.2959928027163772,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}