{"id":"W4389222107","doi":"10.1182/blood-2023-173955","title":"A Phase 1 Cohort Dose Escalation and Expansion Trial to Determine the Safety, Tolerance, Maximum Tolerated Dose, and Preliminary Antineoplastic Activity of IKS03 in Patients with Advanced B-Cell Non-Hodgkin Lymphomas (NHL)","year":2023,"lang":"en","type":"article","venue":"Blood","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Jewish General Hospital","funders":"","keywords":"Cancer research; Antibody-drug conjugate; Radioimmunotherapy; In vivo; Medicine; Lymphoma; Follicular lymphoma; Chemistry; Pharmacology; Antibody; Internal medicine; Immunology; Biology; Monoclonal antibody","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001071901,0.001173012,0.001068695,0.0003379369,0.0003761321,0.0007864884,0.0006994808,0.0008925701,0.004350892],"category_scores_gemma":[0.0005357356,0.0003618868,0.0007591181,0.0003086831,0.0008138109,0.0008247332,0.0003203505,0.003012237,0.00112798],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001235287,"about_ca_system_score_gemma":0.001154649,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007179073,"about_ca_topic_score_gemma":0.001777942,"domain_scores_codex":[0.9997254,0.00008569242,0.00001151615,0.00005640626,0.00003014563,0.00009082899],"domain_scores_gemma":[0.9994741,0.00006506716,0.00009199615,0.00006703083,0.00003820216,0.0002636271],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.5376936,0.1610645,0.01724181,0.0005598295,0.0009681432,0.0005725524,0.0009124505,0.005249248,0.09712919,0.0008694351,0.009486059,0.1682533],"study_design_scores_gemma":[0.288688,0.6789899,0.01602166,0.00003058433,0.0002479959,0.0005182957,0.0001163518,0.002112812,0.008405829,0.0006412592,0.004196294,0.00003107628],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9945787,0.0006853475,0.0004594316,0.0002669149,0.00006722778,0.001481799,0.0007056469,0.00009762619,0.001657221],"genre_scores_gemma":[0.9910492,0.0004657872,0.001257755,0.0006353159,0.00006656013,0.001980846,0.001717934,0.00003103355,0.002795679],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004350892,"threshold_uncertainty_score":0.01455522,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01201076795889282,"score_gpt":0.275547729114953,"score_spread":0.2635369611560602,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}