{"id":"W4389222208","doi":"10.1182/blood-2023-174891","title":"The XPO1-FOXC1-HOX Functional Axis Opens New Therapeutic Avenues to Treat DEK-NUP214 AML Patients","year":2023,"lang":"en","type":"article","venue":"Blood","topic":"Acute Myeloid Leukemia Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Institute for Research in Immunology and Cancer; Centre Hospitalier Universitaire Sainte-Justine","funders":"Gilead Sciences; Janssen Pharmaceuticals; AstraZeneca; Astellas Pharma; Bristol-Myers Squibb; Amgen","keywords":"Biology; Transcriptome; Karyotype; Fusion protein; Myeloid leukemia; Cancer research; Bioinformatics; Internal medicine; Computational biology; Genetics; Gene; Chromosome; Medicine; Gene expression","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001699748,0.00021159,0.0003534543,0.0002314246,0.0001627035,0.0004363477,0.0002495975,0.0002632556,0.002743322],"category_scores_gemma":[0.0001510739,0.0000732362,0.0002138857,0.000187767,0.000206935,0.0002388977,0.000339334,0.000530612,0.0003438301],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003776336,"about_ca_system_score_gemma":0.0002885316,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002680107,"about_ca_topic_score_gemma":0.0008432496,"domain_scores_codex":[0.9999479,0.000006427167,0.000003513782,0.00001294961,0.00001577829,0.00001346855],"domain_scores_gemma":[0.9999512,0.000008096472,0.00001328786,0.000005448273,0.000007517097,0.00001443254],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.003043162,0.0005612048,0.02689603,0.0008592966,0.0002113167,0.00107278,0.0001344444,0.002286923,0.5782362,0.003723553,0.006779553,0.3761955],"study_design_scores_gemma":[0.001328127,0.00576524,0.1507563,0.0004287348,0.000625276,0.00982927,0.0006276987,0.007584844,0.5295464,0.006671682,0.2867567,0.00007958071],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.907467,0.06517988,0.008148713,0.004629259,0.0002210987,0.0001725969,0.001674984,0.0004067826,0.01209965],"genre_scores_gemma":[0.9728417,0.01561326,0.004872043,0.0008233828,0.0001046819,0.0001015736,0.001541092,0.00003720279,0.00406502],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002743322,"threshold_uncertainty_score":0.009177387,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03928453400091457,"score_gpt":0.3005046372473704,"score_spread":0.2612201032464558,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}