{"id":"W4389223918","doi":"10.3389/fcvm.2023.1286241","title":"Rationale and design of the Children's Oncology Group study AAML1831 integrated cardiac substudies in pediatric acute myeloid leukemia therapy","year":2023,"lang":"en","type":"article","venue":"Frontiers in Cardiovascular Medicine","topic":"Chemotherapy-induced cardiotoxicity and mitigation","field":"Medicine","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children","funders":"National Cancer Institute; National Heart, Lung, and Blood Institute; Jazz Pharmaceuticals","keywords":"Dexrazoxane; Cardiotoxicity; Medicine; Anthracycline; Daunorubicin; Oncology; Cytarabine; Internal medicine; Myeloid leukemia; Leukemia; Cancer; Chemotherapy; Breast cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002693101,0.0002707713,0.001409163,0.0005823811,0.00008139812,0.000005457982,0.0001620494,0.0002002524,0.00000400022],"category_scores_gemma":[0.0002129542,0.0001863064,0.0003653047,0.00199135,0.0002822028,0.00007410318,0.00005994539,0.0004777633,0.000001144218],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004607746,"about_ca_system_score_gemma":0.0002633703,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003017098,"about_ca_topic_score_gemma":0.00002148309,"domain_scores_codex":[0.9972358,0.0007293813,0.0005335539,0.0004734408,0.000717441,0.0003103462],"domain_scores_gemma":[0.9989735,0.0001613364,0.0001158787,0.0005554977,0.0001182408,0.00007551014],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0006452731,0.0002101885,0.9119487,0.00008111215,0.005667005,0.0001074432,0.009946226,0.00103675,0.005969154,0.000008572873,0.007068707,0.05731082],"study_design_scores_gemma":[0.01104313,0.0007766663,0.9774088,0.0001309077,0.0009993778,0.00003470866,0.006061751,0.0002169591,0.001926185,0.0001121702,0.00109419,0.0001952047],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9498968,0.04312223,0.001720299,0.0005398848,0.000994499,0.003563532,0.00001016244,0.00005485041,0.00009781079],"genre_scores_gemma":[0.9654458,0.03299967,0.0005127561,0.0001719905,0.0004442604,0.0002561525,0.00006700653,0.00003851659,0.00006389189],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.06546,"threshold_uncertainty_score":0.7597355,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01928989370063463,"score_gpt":0.2539083707499981,"score_spread":0.2346184770493634,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}