{"id":"W4389226232","doi":"10.1159/000535021","title":"Response to “Pathogenicity of Variant m.13528A&amp;gt;G in MT-ND5 in Leber’s Hereditary Optic Neuropathy Is Unsupported”","year":2023,"lang":"en","type":"article","venue":"Case Reports in Ophthalmology","topic":"Mitochondrial Function and Pathology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Kensington Health; St. Michael's Hospital; University of Manitoba; University of Toronto","funders":"","keywords":"Medicine; Ophthalmology; Leber's hereditary optic neuropathy; Pathogenicity; Optic neuropathy; Optic nerve; Biology; Microbiology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00104682,0.0008597894,0.001234293,0.0006043936,0.001373857,0.001125996,0.00171434,0.01977414,0.01136779],"category_scores_gemma":[0.007418395,0.0004153326,0.001046835,0.0003614115,0.001240862,0.001345235,0.0009746751,0.01491454,0.005866467],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001731288,"about_ca_system_score_gemma":0.0008589166,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002586909,"about_ca_topic_score_gemma":0.002894768,"domain_scores_codex":[0.9992385,0.0001493357,0.0001892135,0.0001358582,0.0001341888,0.0001529515],"domain_scores_gemma":[0.9972806,0.001144539,0.0002580367,0.0001150919,0.0007534105,0.0004483912],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"case_report","study_design_scores_codex":[0.0004337838,0.0001084821,0.001835367,0.0002786138,0.00004811337,0.02724934,0.0001735609,0.0002397316,0.00109698,0.001163334,0.9578358,0.00953683],"study_design_scores_gemma":[0.0005848042,0.0005568364,0.01173368,0.0008290207,0.0001245341,0.03357331,0.001306788,0.00190337,0.002263376,0.006393184,0.9405152,0.0002160017],"study_design_candidate":"case_report","study_design_consensus":null,"genre_codex":"commentary","genre_gemma":"empirical","genre_scores_codex":[0.006438031,0.001400437,0.0005635885,0.9291938,0.05401491,0.0002226309,0.0006637627,0.0003356195,0.007167199],"genre_scores_gemma":[0.03591881,0.002004775,0.001191678,0.8493931,0.08725279,0.0002458719,0.0005308322,0.0001254301,0.02333676],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.01977414,"threshold_uncertainty_score":0.03802907,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03108202646894224,"score_gpt":0.3058732109066319,"score_spread":0.2747911844376897,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}