{"id":"W4389226682","doi":"10.1016/j.ebiom.2023.104879","title":"Local fistula injection of allogeneic human amnion epithelial cells is safe and well tolerated in patients with refractory complex perianal Crohn's disease: a phase I open label study with long-term follow up","year":2023,"lang":"en","type":"article","venue":"EBioMedicine","topic":"Mesenchymal stem cell research","field":"Medicine","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Gastroenterological Society of Australia; McMaster University","keywords":"Refractory (planetary science); Amnion; Medicine; Crohn's disease; Disease; Immunology; Surgery; Pathology; Biology; Pregnancy","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001850138,0.00059647,0.00196676,0.0002954609,0.000267364,0.0006791921,0.0003533192,0.0007071943,0.001502881],"category_scores_gemma":[0.001242331,0.0002954558,0.0009350486,0.0003083748,0.0009374312,0.0006844919,0.0002338119,0.001359332,0.0003125896],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002795354,"about_ca_system_score_gemma":0.0004893591,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001752172,"about_ca_topic_score_gemma":0.0002759739,"domain_scores_codex":[0.9995333,0.0002411772,0.00003972934,0.00006703031,0.00005301458,0.00006576168],"domain_scores_gemma":[0.9986514,0.000420831,0.000403058,0.0001441255,0.00006124511,0.0003193298],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.5477522,0.09607068,0.03131565,0.002302559,0.001654276,0.001029014,0.001161318,0.002080868,0.100253,0.0001587639,0.001250035,0.2149717],"study_design_scores_gemma":[0.08986971,0.8768332,0.02642301,0.00005617214,0.0003681768,0.0005735703,0.0001257693,0.0006872834,0.003997363,0.00005573676,0.0009865181,0.00002353011],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9975863,0.00158401,0.0002582389,0.00005354619,0.00001573646,0.0002358562,0.00005044482,0.00001562895,0.0002002449],"genre_scores_gemma":[0.9978331,0.0007909585,0.0005146429,0.0001352279,0.00006457114,0.0003123161,0.0001306705,0.000005425814,0.0002131924],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00196676,"threshold_uncertainty_score":0.009784579,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05309319208611996,"score_gpt":0.3626245830688334,"score_spread":0.3095313909827134,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}