{"id":"W4389226682","doi":"10.1016/j.ebiom.2023.104879","title":"Local fistula injection of allogeneic human amnion epithelial cells is safe and well tolerated in patients with refractory complex perianal Crohn's disease: a phase I open label study with long-term follow up","year":2023,"lang":"en","type":"article","venue":"EBioMedicine","topic":"Mesenchymal stem cell research","field":"Medicine","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Gastroenterological Society of Australia; McMaster University","keywords":"Refractory (planetary science); Amnion; Medicine; Crohn's disease; Disease; Immunology; Surgery; Pathology; Biology; Pregnancy","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005971971,0.0003030731,0.0007242336,0.0005596975,0.000143657,0.00003383892,0.000227279,0.00008250918,0.0007633169],"category_scores_gemma":[0.00002950226,0.0002080311,0.00002652041,0.001103167,0.0004211292,0.0001236921,0.0002100415,0.0002854252,0.0000309721],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001781985,"about_ca_system_score_gemma":0.0002008782,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009053101,"about_ca_topic_score_gemma":0.0004652736,"domain_scores_codex":[0.9970981,0.0002037872,0.0005331879,0.0006310025,0.0010846,0.0004492647],"domain_scores_gemma":[0.9985417,0.00006517359,0.000185206,0.0004757853,0.0002803106,0.0004518138],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.03369927,0.008460392,0.9146153,0.0006543992,0.0003911005,0.002076037,0.002101989,0.000008771844,0.02907363,0.000002332626,0.002263692,0.006653088],"study_design_scores_gemma":[0.06116255,0.01871789,0.9173881,0.000484328,0.0001800629,0.000008053064,0.0005238943,0.0003315624,0.0007221192,0.000001977386,0.0002720032,0.0002074263],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9961516,0.0000586171,0.00007180581,0.0002255493,0.00009382395,0.003075108,0.00007985147,0.00003667773,0.0002070205],"genre_scores_gemma":[0.9965445,0.0000170235,0.00002980832,0.0001103752,0.00008186417,0.00006831941,0.0007690154,0.00005166048,0.00232741],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02835151,"threshold_uncertainty_score":0.8483261,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05309319208611996,"score_gpt":0.3626245830688334,"score_spread":0.3095313909827134,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}