{"id":"W4389227464","doi":"10.1158/1535-7163.targ-23-lb_c11","title":"Abstract LB_C11: Small-molecule bifunctional inhibitors of PARP1/2 and HDAC enzymes","year":2023,"lang":"en","type":"article","venue":"Molecular Cancer Therapeutics","topic":"PARP inhibition in cancer therapy","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"","keywords":"Olaparib; PARP1; PARP inhibitor; Histone deacetylase; Pharmacology; Cancer research; Vorinostat; DNA repair; Poly ADP ribose polymerase; Synthetic lethality; Biology; Polymerase; Histone; Enzyme; Biochemistry; DNA","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002142188,0.0006875173,0.0004114931,0.0005008677,0.0002025292,0.0003697278,0.0005098043,0.0004862742,0.004636042],"category_scores_gemma":[0.00009565122,0.0001544773,0.000303876,0.0005013879,0.0002177094,0.00033526,0.000187959,0.0009875181,0.001568615],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006586466,"about_ca_system_score_gemma":0.0003707537,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0011175,"about_ca_topic_score_gemma":0.00137147,"domain_scores_codex":[0.9998517,0.00002058954,0.0000125781,0.00003326283,0.00004537458,0.00003637191],"domain_scores_gemma":[0.9999366,0.00000688556,0.00001316545,0.000006549552,0.00001182834,0.00002506525],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00115411,0.0004573987,0.000347927,0.0005105574,0.00005370849,0.0002179093,0.00001914637,0.0006568848,0.9513683,0.0006522281,0.005139605,0.03942219],"study_design_scores_gemma":[0.0005828306,0.003758859,0.003658231,0.00005161046,0.0001058122,0.001291083,0.00002173994,0.002985446,0.9535499,0.0001065408,0.03384789,0.00004007015],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8173666,0.09005043,0.03498847,0.001713509,0.001058413,0.000893956,0.01343577,0.003052237,0.03744065],"genre_scores_gemma":[0.9418808,0.01696135,0.01182868,0.0006327693,0.00009996421,0.000354919,0.008832254,0.00007452914,0.01933483],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004636042,"threshold_uncertainty_score":0.01550913,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04751386002510425,"score_gpt":0.3201666676653768,"score_spread":0.2726528076402725,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}