{"id":"W4389227555","doi":"10.1158/1535-7163.targ-23-b045","title":"Abstract B045: Ataxia telangiectasia- and Rad3-related kinase inhibitor (ATRi) camonsertib in combination with low dose gemcitabine in patients with solid tumors with DNA damage response (DDR) aberrations: Preclinical and Phase 1b results","year":2023,"lang":"en","type":"article","venue":"Molecular Cancer Therapeutics","topic":"Cancer Genomics and Diagnostics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre","funders":"","keywords":"Tolerability; Medicine; Gemcitabine; Internal medicine; Response Evaluation Criteria in Solid Tumors; Pharmacology; Oncology; Clinical trial; Cancer; Phases of clinical research; Adverse effect","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005037174,0.0004851172,0.0008506893,0.0004270568,0.0002044297,0.0004819928,0.0004896755,0.0003926632,0.004381392],"category_scores_gemma":[0.0003507625,0.0001653998,0.0003910476,0.0003593556,0.0002579169,0.0003285686,0.0002410535,0.001060841,0.000681871],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005404369,"about_ca_system_score_gemma":0.0006085186,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009531857,"about_ca_topic_score_gemma":0.002929912,"domain_scores_codex":[0.9998131,0.00007374247,0.00001636206,0.00003041735,0.00002912048,0.00003725713],"domain_scores_gemma":[0.9998273,0.00002550197,0.00003740359,0.00001104908,0.00001324318,0.00008550115],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.3177482,0.02946935,0.01251748,0.001865346,0.001239094,0.0006309733,0.0002799451,0.003948375,0.2611518,0.000576128,0.01094706,0.3596262],"study_design_scores_gemma":[0.1735581,0.6765706,0.06390296,0.000231642,0.001394539,0.001604588,0.0001499382,0.005406528,0.05933902,0.0003385076,0.01744206,0.00006152394],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9914976,0.003071117,0.0003098712,0.0002840483,0.00004276489,0.0004615284,0.0009332675,0.00009998,0.003299757],"genre_scores_gemma":[0.9932209,0.001360266,0.0008632001,0.0002293824,0.00005211556,0.0003001977,0.001888442,0.00001761809,0.002067929],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004381392,"threshold_uncertainty_score":0.0146572,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01064044508449267,"score_gpt":0.2818753531656338,"score_spread":0.2712349080811411,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}