{"id":"W4389227639","doi":"10.1158/2326-6074.tumimm23-a006","title":"Abstract A006: Understanding the Potential of Human IL-12 and Chimeric IL-15 Combination for Cancer Immunotherapy","year":2023,"lang":"en","type":"article","venue":"Cancer Immunology Research","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Immunotherapy; Interleukin 15; Cancer immunotherapy; Immunology; Cytotoxic T cell; Chimeric antigen receptor; CD8; T cell; Cancer research; STAT4; Biology; Immune system; Medicine; Cytokine; Interleukin; In vitro; stat; STAT3; Cell biology; Signal transduction","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001709396,0.0002486309,0.0001532397,0.0001607217,0.00005490812,0.0002906745,0.000209066,0.0002832065,0.001740611],"category_scores_gemma":[0.00007813465,0.00008199787,0.0002248267,0.00009301368,0.0001272809,0.0002866203,0.0000922527,0.0003180105,0.0004619043],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003042029,"about_ca_system_score_gemma":0.0001907933,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003847466,"about_ca_topic_score_gemma":0.0003000863,"domain_scores_codex":[0.9999396,0.00001162134,0.000004056944,0.00001168278,0.0000186483,0.00001451184],"domain_scores_gemma":[0.9999826,0.000003573627,0.000005159113,0.000001309086,0.000002959193,0.000004387452],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000288426,0.0001000901,0.0005103594,0.0002068526,0.00001566586,0.000091791,0.00001248563,0.00176328,0.9782851,0.001181616,0.0004522927,0.017092],"study_design_scores_gemma":[0.00008235666,0.001732266,0.002431862,0.00004562929,0.00006280667,0.0007141783,0.00002667891,0.01939301,0.952861,0.001316684,0.02131933,0.00001413214],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8376667,0.07986133,0.0657643,0.001797854,0.0003046888,0.0003025963,0.0007095877,0.0003216291,0.01327128],"genre_scores_gemma":[0.9784848,0.007008704,0.01061653,0.0002950848,0.00005912151,0.00006774715,0.0002220979,0.00001155134,0.003234284],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001740611,"threshold_uncertainty_score":0.005822897,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1543364995152396,"score_gpt":0.4428773898484035,"score_spread":0.288540890333164,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}