{"id":"W4389227665","doi":"10.1158/1535-7163.targ-23-pr008","title":"Abstract PR008: MYTHIC: First-in-human (FIH) biomarker-driven phase I trial of PKMYT1 inhibitor lunresertib (lunre) alone and with ATR inhibitor camonsertib (cam) in solid tumors with <i>CCNE1</i> amplification or deleterious alterations in <i>FBXW7</i> or <i>PPP2R1A</i>","year":2023,"lang":"en","type":"article","venue":"Molecular Cancer Therapeutics","topic":"Cancer Genomics and Diagnostics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":20,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre","funders":"","keywords":"Medicine; Tolerability; Nausea; Internal medicine; Rash; Oncology; Gastroenterology; Adverse effect; Pharmacology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0002673861,0.0004174584,0.0005335577,0.0002867358,0.0001053081,0.00007996714,0.0002554226,0.0002420855,0.000009441017],"category_scores_gemma":[0.00003612762,0.0003432895,0.00007362226,0.0007776513,0.0002324234,0.00002347657,0.0001056522,0.0002495358,0.000001291146],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001359357,"about_ca_system_score_gemma":0.0005927672,"about_ca_topic_candidate":true,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001042293,"about_ca_topic_score_gemma":0.03421643,"domain_scores_codex":[0.9975194,0.00009599848,0.000798152,0.0007235946,0.0003118706,0.0005509522],"domain_scores_gemma":[0.9987675,0.00007505162,0.0003097566,0.0005731538,0.0001409581,0.0001335959],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.04442033,0.0008774353,0.00636031,0.0001869164,0.0001690238,0.0002881032,0.0007545863,0.0047719,0.9386413,0.00001424778,0.0002033041,0.003312526],"study_design_scores_gemma":[0.1182274,0.008805136,0.01181785,0.001315351,0.000244388,0.00007117826,0.0007029522,0.002882977,0.8435844,0.00007615017,0.01044722,0.001824984],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9961936,0.0008699643,0.0003994015,0.0006964075,0.0001288356,0.001447558,0.0001945232,0.00002409946,0.00004562648],"genre_scores_gemma":[0.9961713,0.001775127,0.0002937619,0.0006658717,0.0001328012,0.0005117391,0.000283104,0.0001039488,0.00006237165],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.09505688,"threshold_uncertainty_score":0.9999019,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02804619337130081,"score_gpt":0.3158654870682814,"score_spread":0.2878192936969806,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}