{"id":"W4389227665","doi":"10.1158/1535-7163.targ-23-pr008","title":"Abstract PR008: MYTHIC: First-in-human (FIH) biomarker-driven phase I trial of PKMYT1 inhibitor lunresertib (lunre) alone and with ATR inhibitor camonsertib (cam) in solid tumors with <i>CCNE1</i> amplification or deleterious alterations in <i>FBXW7</i> or <i>PPP2R1A</i>","year":2023,"lang":"en","type":"article","venue":"Molecular Cancer Therapeutics","topic":"Cancer Genomics and Diagnostics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":20,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre","funders":"","keywords":"Medicine; Tolerability; Nausea; Internal medicine; Rash; Oncology; Gastroenterology; Adverse effect; Pharmacology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000927548,0.001151357,0.00130043,0.0003601441,0.0003908806,0.0008106596,0.0008681241,0.001211363,0.01125628],"category_scores_gemma":[0.0004791456,0.0004658792,0.0007726272,0.000252249,0.0006246426,0.0007666247,0.0003869971,0.003008442,0.001784567],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001120826,"about_ca_system_score_gemma":0.001487903,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009489811,"about_ca_topic_score_gemma":0.003001749,"domain_scores_codex":[0.9997955,0.00006375488,0.000007950568,0.00004282289,0.00002320793,0.00006675187],"domain_scores_gemma":[0.9996868,0.0000272614,0.00004668251,0.00002166102,0.00001769705,0.0001997861],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.6905413,0.03656945,0.005637235,0.001126333,0.0009881057,0.000403329,0.0002151309,0.002957892,0.07472485,0.0012902,0.03487742,0.1506688],"study_design_scores_gemma":[0.5216651,0.4433392,0.01274145,0.00007155055,0.0004221489,0.0006324177,0.00004841833,0.001472061,0.008013615,0.0004770094,0.01107346,0.00004367745],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9732963,0.002434104,0.0008841419,0.001432424,0.0002241087,0.00503601,0.007083997,0.0005565274,0.009052455],"genre_scores_gemma":[0.9717143,0.001093005,0.002806748,0.001847241,0.0001999985,0.0033453,0.008267012,0.00009350552,0.01063294],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01125628,"threshold_uncertainty_score":0.03765601,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02804619337130081,"score_gpt":0.3158654870682814,"score_spread":0.2878192936969806,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}