{"id":"W4389227682","doi":"10.1158/2326-6074.tumimm23-b028","title":"Abstract B028: WEE1 inhibition enhances the antitumor immune response to PD-L1 blockade by the concomitant activation of STING and STAT1 pathways in small cell lung cancer","year":2023,"lang":"en","type":"article","venue":"Cancer Immunology Research","topic":"Lung Cancer Research Studies","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Wee1; Cancer research; Immune checkpoint; Cell cycle checkpoint; Blockade; Immunotherapy; Cell cycle; Medicine; Biology; Immunology; Immune system; Cancer; Cyclin-dependent kinase 1; Internal medicine","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001052619,0.0004084148,0.0003053553,0.0002507164,0.0001344642,0.0002621099,0.0002318502,0.0002658237,0.003767797],"category_scores_gemma":[0.00007342955,0.0001071494,0.0002752741,0.0001699633,0.000183181,0.0001996979,0.0001401623,0.0009343614,0.0006139594],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002292276,"about_ca_system_score_gemma":0.0003628833,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006548695,"about_ca_topic_score_gemma":0.001129448,"domain_scores_codex":[0.9999179,0.00001252733,0.000007169103,0.000011138,0.00001775474,0.00003358433],"domain_scores_gemma":[0.9999481,0.000005923803,0.000008896211,0.000004151239,0.000005703715,0.00002707103],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001769379,0.0005809328,0.0002297468,0.0001328877,0.00001893944,0.00004688769,0.00001870364,0.0002224868,0.991706,0.0001107591,0.0004843707,0.004678917],"study_design_scores_gemma":[0.0003765243,0.007155681,0.003861113,0.00001619058,0.00004339365,0.0002071355,0.00003257774,0.001815166,0.9823499,0.00005291561,0.004081971,0.000007382942],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9949793,0.001364343,0.0006897934,0.0001617705,0.00005847965,0.00004876814,0.0005134461,0.0001358952,0.002048255],"genre_scores_gemma":[0.995172,0.0005543195,0.0007112447,0.0000758713,0.00001147821,0.00007346962,0.0008867459,0.00001514361,0.002499676],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003767797,"threshold_uncertainty_score":0.01260453,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07118017525727223,"score_gpt":0.4046953547627054,"score_spread":0.3335151795054332,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}