{"id":"W4389227710","doi":"10.1158/1535-7163.targ-23-a123","title":"Abstract A123: Circulating tumor DNA (ctDNA) genomic and epigenomic profiling (GuardantINFINITY) for diagnosis of DNA damage repair (DDR) loss of function (LOF) and response monitoring in the TRESR and ATTACC trials","year":2023,"lang":"en","type":"article","venue":"Molecular Cancer Therapeutics","topic":"Cancer Genomics and Diagnostics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre","funders":"","keywords":"Olaparib; PALB2; Cancer research; Biology; CHEK2; BRCA2 Protein; Internal medicine; Oncology; Genetics; Medicine; Germline mutation; Mutation; Gene; Poly ADP ribose polymerase","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001702283,0.0003879431,0.000697218,0.0003647763,0.0001978808,0.0007330432,0.0003636764,0.0004340929,0.009176145],"category_scores_gemma":[0.00144368,0.0001629502,0.0004370071,0.0004833952,0.0002577296,0.0003330723,0.0002909137,0.000735041,0.001444795],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000516289,"about_ca_system_score_gemma":0.0005880444,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004817958,"about_ca_topic_score_gemma":0.001286221,"domain_scores_codex":[0.999207,0.0003487471,0.00007156627,0.0001714111,0.0001427916,0.00005846766],"domain_scores_gemma":[0.9987212,0.0003537764,0.0003665399,0.00008071615,0.0002277827,0.0002500027],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"observational","study_design_scores_codex":[0.1192684,0.001519376,0.2266818,0.002014509,0.001180634,0.0006355432,0.0001906365,0.00227293,0.1138373,0.0009153223,0.04170109,0.4897824],"study_design_scores_gemma":[0.03047861,0.08373244,0.6550682,0.0007152431,0.003622459,0.006655292,0.0002445088,0.009983543,0.1077714,0.002000001,0.09960061,0.0001277342],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9479559,0.009790144,0.003023507,0.001809654,0.0002114946,0.001121726,0.01603121,0.0005797161,0.01947651],"genre_scores_gemma":[0.9738548,0.001554802,0.005187604,0.001007754,0.0002343613,0.0007870973,0.01277813,0.00008199239,0.004513331],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.009176145,"threshold_uncertainty_score":0.03069723,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05445792351080183,"score_gpt":0.3262254619171759,"score_spread":0.2717675384063741,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}