{"id":"W4389227721","doi":"10.1158/2326-6074.tumimm23-b024","title":"Abstract B024: TrkB.T1 receptor promotes an immunosuppressive microenvironment driven by neutrophil recruitment in gliomas","year":2023,"lang":"en","type":"article","venue":"Cancer Immunology Research","topic":"Neuroinflammation and Neurodegeneration Mechanisms","field":"Neuroscience","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Tropomyosin receptor kinase B; Glioma; Tumor microenvironment; Cancer research; Immune system; Neurotrophic factors; Biology; Paracrine signalling; Downregulation and upregulation; Brain-derived neurotrophic factor; Immunology; Tropomyosin receptor kinase A; Medicine; Receptor; Neurotrophin; Internal medicine","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001131039,0.0002611823,0.0002261325,0.0002429322,0.0001008722,0.000258915,0.0001354447,0.0002774876,0.002014507],"category_scores_gemma":[0.000082232,0.0001087723,0.0002092333,0.0001108769,0.0001681554,0.0001365101,0.0001075172,0.0005476035,0.00068998],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001935873,"about_ca_system_score_gemma":0.0001248757,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004282971,"about_ca_topic_score_gemma":0.0003708006,"domain_scores_codex":[0.9998726,0.00002157619,0.00001004346,0.00002284455,0.00002668243,0.00004631564],"domain_scores_gemma":[0.9998893,0.00001264021,0.00003796501,0.000007811098,0.00001372213,0.00003860033],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002513748,0.00004518384,0.0001993386,0.00003024115,0.000002609973,0.0001119124,0.000007421584,0.00001879767,0.9986602,0.00003582225,0.00005004186,0.0005869764],"study_design_scores_gemma":[0.0001060403,0.001644111,0.01730093,0.00001352913,0.00003230986,0.002046198,0.00009474587,0.001028879,0.9751034,0.00007871093,0.002543156,0.000007882732],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9963103,0.001477728,0.0009064834,0.0001128717,0.00003331204,0.0000214489,0.0002345153,0.0000568377,0.00084661],"genre_scores_gemma":[0.9961613,0.0005134779,0.0006927957,0.00006576579,0.00001961316,0.00002972038,0.0003251902,0.0000159879,0.00217609],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002014507,"threshold_uncertainty_score":0.006739259,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1831892383113972,"score_gpt":0.4003265696749317,"score_spread":0.2171373313635345,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}