{"id":"W4389227749","doi":"10.1158/2326-6074.tumimm23-a023","title":"Abstract A023: Nicotinamide Phosphoribosyltransferase (NAMPT) is required for trained macrophage-mediated antitumor immunity","year":2023,"lang":"en","type":"article","venue":"Cancer Immunology Research","topic":"Immune responses and vaccinations","field":"Immunology and Microbiology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Nicotinamide phosphoribosyltransferase; Cancer research; NAD+ kinase; Immune system; Innate immune system; Nicotinamide mononucleotide; Nicotinamide adenine dinucleotide; Immunity; Cancer immunotherapy; PI3K/AKT/mTOR pathway; Medicine; Immunotherapy; Immunology; Biology; Biochemistry; Apoptosis; Enzyme","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001305102,0.0003611379,0.000324153,0.000204223,0.0003305247,0.0003902289,0.0003596415,0.0004673672,0.005857017],"category_scores_gemma":[0.0000749568,0.0001374428,0.0002516717,0.0001493735,0.0002862716,0.0002523647,0.0002428896,0.0006478698,0.00160777],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003946892,"about_ca_system_score_gemma":0.0004072294,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006992826,"about_ca_topic_score_gemma":0.0008853531,"domain_scores_codex":[0.9999228,0.000006772215,0.000007589304,0.00002391662,0.0000241478,0.00001466699],"domain_scores_gemma":[0.999933,0.000004525447,0.00001697151,0.000004582886,0.00001284346,0.00002810374],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003271285,0.00002383711,0.0002696979,0.0001192392,0.000007615479,0.0002080803,0.00001261554,0.00003624113,0.9931859,0.0002453137,0.0009943144,0.004570044],"study_design_scores_gemma":[0.00007852064,0.0003282403,0.02594344,0.00003495768,0.00005510078,0.001397904,0.00008455514,0.0008949585,0.9339848,0.0004347688,0.03674437,0.00001830868],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8859806,0.03857453,0.0229716,0.004006624,0.004155724,0.0002381517,0.005186836,0.002337034,0.03654886],"genre_scores_gemma":[0.8947414,0.01303406,0.007117435,0.0008154656,0.0005345901,0.0001718946,0.004967282,0.0002173468,0.07840061],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005857017,"threshold_uncertainty_score":0.01959372,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07881101901085927,"score_gpt":0.3907829523918303,"score_spread":0.311971933380971,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}