{"id":"W4389227749","doi":"10.1158/2326-6074.tumimm23-a023","title":"Abstract A023: Nicotinamide Phosphoribosyltransferase (NAMPT) is required for trained macrophage-mediated antitumor immunity","year":2023,"lang":"en","type":"article","venue":"Cancer Immunology Research","topic":"Immune responses and vaccinations","field":"Immunology and Microbiology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Nicotinamide phosphoribosyltransferase; Cancer research; NAD+ kinase; Immune system; Innate immune system; Nicotinamide mononucleotide; Nicotinamide adenine dinucleotide; Immunity; Cancer immunotherapy; PI3K/AKT/mTOR pathway; Medicine; Immunotherapy; Immunology; Biology; Biochemistry; Apoptosis; Enzyme","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","sts","insufficient_payload"],"consensus_categories":["insufficient_payload"],"category_scores_codex":[0.002599525,0.0004038596,0.0006744524,0.0009354666,0.001714303,0.00007009441,0.001127864,0.0007531461,0.004178919],"category_scores_gemma":[0.001280266,0.000391829,0.0003423826,0.001857329,0.0009818365,0.0002281558,0.000287509,0.0016657,0.003059187],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003367738,"about_ca_system_score_gemma":0.0009072901,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001483837,"about_ca_topic_score_gemma":0.0001350355,"domain_scores_codex":[0.9955273,0.0007427845,0.0007493439,0.0007873389,0.0001574102,0.002035792],"domain_scores_gemma":[0.9954618,0.002442768,0.000136021,0.001011636,0.0008751478,0.000072675],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.003109096,0.0002511845,0.0007749809,0.000106313,0.0007929929,0.00003630613,0.00117742,0.000006319777,0.9441545,0.000907794,0.03325685,0.01542624],"study_design_scores_gemma":[0.009354253,0.0009101916,0.136344,0.0001603735,0.00007430283,0.00006537267,0.002397459,0.00007139274,0.6346808,0.0007857242,0.2144415,0.000714688],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9645188,0.0240535,0.0000657303,0.005440509,0.001841684,0.001610057,0.001418523,0.0004504687,0.0006007022],"genre_scores_gemma":[0.9694846,0.007639771,0.00002518655,0.0001723066,0.00008304232,0.001346948,0.001317448,0.00009934839,0.01983133],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3094737,"threshold_uncertainty_score":0.9998534,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07881101901085927,"score_gpt":0.3907829523918303,"score_spread":0.311971933380971,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}