{"id":"W4389227766","doi":"10.1158/2326-6074.tumimm23-a031","title":"Abstract A031: Discovery and characterization of a novel, immunoproteasome activator that modulates the immunopeptidome, increases MHC class I antigenic presentation and enhances antitumor immunity","year":2023,"lang":"en","type":"article","venue":"Cancer Immunology Research","topic":"Ubiquitin and proteasome pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"MHC class I; Cytotoxic T cell; Antigen presentation; Biology; Cancer immunotherapy; Antigen processing; CD8; Antigen; Immunotherapy; Major histocompatibility complex; Antigen-presenting cell; T cell; Immune system; Cell biology; Immunology; Biochemistry; In vitro","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001565816,0.0004225125,0.0002930712,0.0002169847,0.0001127434,0.000348099,0.0002786315,0.0004535407,0.001865577],"category_scores_gemma":[0.0001057109,0.00009494694,0.0004012863,0.0002057973,0.0001078511,0.0001488655,0.0001369574,0.0004806133,0.0009361315],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002117735,"about_ca_system_score_gemma":0.0002260565,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000191905,"about_ca_topic_score_gemma":0.0002384539,"domain_scores_codex":[0.9999191,0.00001100982,0.000008795983,0.00001652371,0.00002589029,0.0000187302],"domain_scores_gemma":[0.9999443,0.000006902832,0.00001063178,0.000004510014,0.00001080034,0.00002281767],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000129373,0.00007545275,0.00009759619,0.00004418366,0.000007787167,0.00007648419,0.000003992862,0.0000905819,0.9965,0.0000461123,0.00012355,0.002804803],"study_design_scores_gemma":[0.000102483,0.001340812,0.001703286,0.000009776628,0.00003197048,0.0005680013,0.00001256985,0.0009229864,0.989537,0.0000663089,0.005696181,0.000008568069],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.968227,0.008949678,0.0141931,0.000413537,0.0001751426,0.0004034409,0.002696064,0.0002279406,0.004714184],"genre_scores_gemma":[0.9741599,0.003233236,0.01156228,0.0003856654,0.00005236891,0.0001442295,0.005038703,0.00005585184,0.005367696],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001865577,"threshold_uncertainty_score":0.006240964,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05364336927404059,"score_gpt":0.3386999992972575,"score_spread":0.2850566300232169,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}