{"id":"W4389227766","doi":"10.1158/2326-6074.tumimm23-a031","title":"Abstract A031: Discovery and characterization of a novel, immunoproteasome activator that modulates the immunopeptidome, increases MHC class I antigenic presentation and enhances antitumor immunity","year":2023,"lang":"en","type":"article","venue":"Cancer Immunology Research","topic":"Ubiquitin and proteasome pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"MHC class I; Cytotoxic T cell; Antigen presentation; Biology; Cancer immunotherapy; Antigen processing; CD8; Antigen; Immunotherapy; Major histocompatibility complex; Antigen-presenting cell; T cell; Immune system; Cell biology; Immunology; Biochemistry; In vitro","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001130985,0.0001947219,0.000253905,0.0001824645,0.000452819,0.0001119839,0.0003714513,0.0001987905,0.00002900794],"category_scores_gemma":[0.0002437851,0.0001525466,0.00005758311,0.000400986,0.001061252,0.00007302478,0.0005750795,0.0003877484,0.00000523541],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000246808,"about_ca_system_score_gemma":0.0001983383,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001077137,"about_ca_topic_score_gemma":0.000048656,"domain_scores_codex":[0.9982517,0.0003587882,0.0002756028,0.0004089407,0.000251131,0.0004538045],"domain_scores_gemma":[0.9988812,0.0001892505,0.0001793071,0.0004962997,0.0002094772,0.0000444627],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005680461,0.00008040894,0.008397787,0.0001066103,0.000204919,0.000001554896,0.0002271412,0.000002331657,0.9868962,0.00008163101,0.0000276118,0.003405798],"study_design_scores_gemma":[0.0004965059,0.0001580112,0.3494664,0.00007433533,0.000008470831,0.00001026598,0.0004858573,0.00003525825,0.6484956,0.00004332823,0.0006099088,0.0001160348],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9918942,0.006690297,0.00002401165,0.0002559245,0.00012245,0.0007306151,0.0001900624,0.00002267173,0.00006970535],"genre_scores_gemma":[0.9767393,0.02191504,0.00001264413,0.00002499536,0.00009860535,0.0003273286,0.0003173468,0.00002989498,0.0005348396],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3410687,"threshold_uncertainty_score":0.622067,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05364336927404059,"score_gpt":0.3386999992972575,"score_spread":0.2850566300232169,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}