{"id":"W4389227770","doi":"10.1158/2326-6074.tumimm23-b003","title":"Abstract B003: Communication is key: Understanding the modulating effect of immune cell crosstalk on T cell therapy function","year":2023,"lang":"en","type":"article","venue":"Cancer Immunology Research","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Tumor microenvironment; Crosstalk; T cell; Immune system; Interactome; CD8; Immunotherapy; Cancer immunotherapy; Cancer research; Cell; Biology; Computational biology; Cell biology; Immunology; Genetics","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002767335,0.000613994,0.0003657214,0.0004322949,0.0004668463,0.001410776,0.0003499758,0.001165096,0.05520948],"category_scores_gemma":[0.0002405057,0.000206134,0.0003433888,0.0003698981,0.0004819613,0.001055941,0.0006311727,0.001367084,0.01268182],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008115597,"about_ca_system_score_gemma":0.0004936982,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000539618,"about_ca_topic_score_gemma":0.0003748998,"domain_scores_codex":[0.9996949,0.00003367902,0.00001557352,0.0000873364,0.00009422329,0.00007416082],"domain_scores_gemma":[0.999828,0.0000397685,0.00003794068,0.00001490682,0.00003217101,0.0000472519],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002346019,0.00004732672,0.0002384957,0.0003197427,0.000009534989,0.0001563763,0.00002577884,0.0002744686,0.9709648,0.003246299,0.003127704,0.0213548],"study_design_scores_gemma":[0.00007820902,0.0003856086,0.007763574,0.0001168757,0.00004139564,0.0006220314,0.0001389411,0.005268165,0.8388541,0.005259684,0.1414466,0.00002481228],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.5840418,0.05942954,0.1086908,0.01746032,0.003869271,0.0003766233,0.01336877,0.004039185,0.2087238],"genre_scores_gemma":[0.8607757,0.01652853,0.02071989,0.001461265,0.0004327605,0.0003169319,0.003856086,0.0004455306,0.09546335],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05520948,"threshold_uncertainty_score":0.1846941,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1534942823542101,"score_gpt":0.4272296002217451,"score_spread":0.2737353178675349,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}