{"id":"W4389227797","doi":"10.1158/2326-6074.tumimm23-a047","title":"Abstract A047: Tumor specific γδ T cells expand and respond to PD-1 blockade","year":2023,"lang":"en","type":"article","venue":"Cancer Immunology Research","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre","funders":"","keywords":"Pembrolizumab; TIGIT; T cell; T-cell receptor; Blockade; Immunology; Cancer immunotherapy; Tumor-infiltrating lymphocytes; Immunotherapy; Biology; Cancer research; Medicine; Immune system; Receptor; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008163391,0.0002251824,0.0001836261,0.0002146869,0.0002011336,0.0002855008,0.0001128845,0.00033202,0.003376808],"category_scores_gemma":[0.0001736449,0.00008257319,0.000175905,0.00008852592,0.0001316147,0.0001131722,0.0001537646,0.0007082543,0.0007009406],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002049961,"about_ca_system_score_gemma":0.0001041672,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006066238,"about_ca_topic_score_gemma":0.0003489885,"domain_scores_codex":[0.9999285,0.0000106277,0.000006578909,0.0000181238,0.00001314081,0.00002312338],"domain_scores_gemma":[0.9999191,0.00002163483,0.000009004987,0.000010377,0.0000149985,0.00002482142],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0005548591,0.0001047201,0.007906327,0.00003952626,0.00001019177,0.001066851,0.0001045721,0.0002288422,0.9797355,0.0001186747,0.0008655642,0.009264371],"study_design_scores_gemma":[0.0003503215,0.004181511,0.1961369,0.00005196755,0.000147845,0.02408331,0.0005453879,0.0061718,0.7418115,0.0006887338,0.02580437,0.00002639554],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9944924,0.0006830369,0.0009212723,0.0001774381,0.00003357738,0.00003687233,0.0002609323,0.0000693687,0.003325195],"genre_scores_gemma":[0.9975342,0.0001018561,0.000473804,0.0001713106,0.00001575948,0.00002273529,0.0002631131,0.00001243123,0.001404763],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003376808,"threshold_uncertainty_score":0.01129657,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1241142598782895,"score_gpt":0.4345827140921795,"score_spread":0.3104684542138901,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}