{"id":"W4389228902","doi":"10.1182/blood-2023-190863","title":"Single-Cell Revelation of Extensive Heterogeneity in the Human Lymphocyte and Neutrophil/Monocyte Lineage Restriction Process Despite Highly Co-Regulated Changes in Cell Cycle Control","year":2023,"lang":"en","type":"article","venue":"Blood","topic":"Immune responses and vaccinations","field":"Immunology and Microbiology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; BC Cancer Agency","funders":"","keywords":"Biology; Progenitor cell; Haematopoiesis; CD19; CD14; Monocyte; CD34; Phenotype; Cell biology; Lineage markers; CD15; Stem cell; Immunology; Molecular biology; Genetics; Flow cytometry; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003232977,0.0001256904,0.0002170949,0.0003017178,0.0001347699,0.00001272224,0.0001141729,0.0001774404,0.000004589624],"category_scores_gemma":[0.00004174016,0.0001050114,0.00003388819,0.0004523693,0.00005351726,0.00006621369,0.00002427349,0.0001453397,0.0000128796],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002682476,"about_ca_system_score_gemma":0.0000310115,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001502729,"about_ca_topic_score_gemma":0.0001450056,"domain_scores_codex":[0.9988738,0.0003690576,0.0002877957,0.000211434,0.00003517037,0.0002227301],"domain_scores_gemma":[0.9993526,0.0002018172,0.0001768561,0.0001844258,0.00007548453,0.000008755547],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002106532,0.0004245901,0.01022604,0.00004575412,0.00002287029,0.0000122994,0.0008562439,0.000179071,0.9877449,0.00003226972,0.00001931982,0.0002260489],"study_design_scores_gemma":[0.007155487,0.0003300873,0.3879029,0.00003815948,0.00005757737,0.00001777718,0.0002985168,0.00007918131,0.6038241,0.0000551097,0.0001283228,0.0001127189],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9973615,0.001764158,0.000007742054,0.0002133775,0.00005753649,0.0004575866,0.00003385989,0.0000362285,0.00006802556],"genre_scores_gemma":[0.9993777,0.0002628503,0.000004894613,0.00005713214,0.00001431424,0.00004412313,0.0001186628,0.00001270892,0.000107645],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3839207,"threshold_uncertainty_score":0.4282239,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01830916221720811,"score_gpt":0.2603946293054145,"score_spread":0.2420854670882064,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}