{"id":"W4389228984","doi":"10.1182/blood-2023-179664","title":"Phase 3b Study Design for a Comparison of Treatment Preference between Oral Decitabine/Cedazuridine and Azacitidine in Adult Patients with IPSS-R Intermediate Myelodysplastic Syndrome, IPSS Intermediate-2 or High-Risk Myelodysplastic Syndrome, Low-Blast Acute Myeloid Leukaemia, or Chronic Myelomonocytic Leukaemia","year":2023,"lang":"en","type":"article","venue":"Blood","topic":"Acute Myeloid Leukemia Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Decitabine; Medicine; International Prognostic Scoring System; Azacitidine; Myelodysplastic syndromes; Internal medicine; Hypomethylating agent; Discontinuation; Chronic myelomonocytic leukemia; Oncology; Population; Dysplasia; Bone marrow; Gastroenterology","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00804186,0.002882514,0.005046417,0.0007861587,0.0007720495,0.00161085,0.001359705,0.002397147,0.02886338],"category_scores_gemma":[0.005861486,0.001005915,0.002816301,0.0009016044,0.001287381,0.001327042,0.0008973997,0.005630775,0.004287192],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001255128,"about_ca_system_score_gemma":0.003908108,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001016189,"about_ca_topic_score_gemma":0.001670283,"domain_scores_codex":[0.996461,0.001905639,0.0002121621,0.0006242357,0.0002870876,0.0005099507],"domain_scores_gemma":[0.996136,0.001078017,0.0006753773,0.0006390198,0.0005539889,0.0009176102],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"not_applicable","study_design_scores_codex":[0.9681405,0.01866568,0.0005029102,0.0002720779,0.0006617483,0.00002364231,0.00003990419,0.0002893836,0.002840152,0.0001978848,0.001215615,0.007150475],"study_design_scores_gemma":[0.6509472,0.3359845,0.003520052,0.00005647485,0.0007526971,0.00004099017,0.00004706399,0.0007165142,0.001255979,0.0005349188,0.006108,0.00003570374],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"protocol","genre_scores_codex":[0.8139897,0.003046476,0.007262323,0.00136932,0.002940743,0.1421604,0.01818119,0.0004376059,0.01061223],"genre_scores_gemma":[0.6696017,0.00154396,0.02135941,0.003610204,0.001171696,0.2720327,0.01042565,0.0002388311,0.02001582],"genre_candidate":"protocol","genre_consensus":null,"teacher_disagreement_score":0.02886338,"threshold_uncertainty_score":0.09655762,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04386852271083277,"score_gpt":0.3226050429776718,"score_spread":0.2787365202668391,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}