{"id":"W4389229148","doi":"10.1182/blood-2023-174076","title":"<i>Calr</i> Variant Allele Frequency in Essential Thrombocythemia: Molecular Associations and Impact on Disease Phenotype and Outcome","year":2023,"lang":"en","type":"article","venue":"Blood","topic":"Myeloproliferative Neoplasms: Diagnosis and Treatment","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Quebec - Clinical Research Organization in Cancer; Université de Montréal; MPB Technologies & Communications (Canada); Hôpital Maisonneuve-Rosemont","funders":"","keywords":"Essential thrombocythemia; Myelofibrosis; Medicine; Internal medicine; Leukocytosis; Gastroenterology; Thrombocytosis; Myeloproliferative neoplasm; Calreticulin; Myeloid; Myeloid leukemia; Allele; Polycythemia vera; Oncology; Genetics; Biology; Gene; Platelet; Bone marrow","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002679663,0.000217189,0.0001812573,0.0005140601,0.0001642802,0.000367537,0.0002372961,0.0004094129,0.001585178],"category_scores_gemma":[0.00095291,0.0001019341,0.0001955781,0.0004734301,0.0002617707,0.000164821,0.0001825878,0.0003255414,0.0001678432],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001549825,"about_ca_system_score_gemma":0.00009780042,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007841898,"about_ca_topic_score_gemma":0.0006748716,"domain_scores_codex":[0.9998441,0.00004024876,0.00001606528,0.00005044898,0.000022044,0.00002704001],"domain_scores_gemma":[0.9992521,0.0002020761,0.0003459277,0.00003682204,0.0000377084,0.0001252633],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0005232634,0.00002456179,0.9951009,0.000008213331,0.00003924124,0.000401463,0.00002335932,0.00006226522,0.001354578,0.00003235392,0.00009171529,0.002338099],"study_design_scores_gemma":[0.00001431255,0.0001558778,0.9962625,0.000005191534,0.00005281782,0.002471623,0.00004005259,0.0004431746,0.0002963497,0.00009315385,0.0001612859,0.000003585804],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9991768,0.0002488899,0.00009400478,0.00003688112,0.000003810499,0.000002185997,0.0001299624,0.00000494018,0.0003025415],"genre_scores_gemma":[0.9997246,0.00004403923,0.00005124733,0.00001187884,0.000009261713,0.000001560394,0.00009172692,0.00000136953,0.00006418373],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001585178,"threshold_uncertainty_score":0.005302966,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0149997247198023,"score_gpt":0.3041925289978127,"score_spread":0.2891928042780104,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}