{"id":"W4389229226","doi":"10.1182/blood-2023-178635","title":"The ELEMENT-MDS Trial: A Phase 3 Randomized Study Evaluating Luspatercept Versus Epoetin Alfa in Erythropoiesis-Stimulating Agent-Naive, Non-Transfusion-Dependent, Lower-Risk Myelodysplastic Syndromes","year":2023,"lang":"en","type":"article","venue":"Blood","topic":"Acute Myeloid Leukemia Research","field":"Medicine","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"Health Sciences Centre; University of Toronto; Sunnybrook Health Science Centre","funders":"","keywords":"Medicine; Myelodysplastic syndromes; Anemia; Internal medicine; Erythropoiesis; Ineffective erythropoiesis; International Prognostic Scoring System; Blood transfusion; Population; Bone marrow","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001191276,0.001164035,0.001910171,0.0002534206,0.0002891526,0.0008094346,0.0006982111,0.001334556,0.007647701],"category_scores_gemma":[0.001294574,0.0003623803,0.0017547,0.0002504982,0.000736762,0.0008228617,0.0004305598,0.00332417,0.0008774138],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005720753,"about_ca_system_score_gemma":0.0007632083,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005195559,"about_ca_topic_score_gemma":0.001608178,"domain_scores_codex":[0.9996674,0.0001929642,0.00001491654,0.00005043728,0.0000307138,0.00004354397],"domain_scores_gemma":[0.9994319,0.0001597381,0.0001583059,0.00003941117,0.00003526665,0.0001752833],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9580879,0.004966892,0.001388111,0.001140358,0.001650697,0.00007322391,0.00006402205,0.0008354246,0.003645208,0.0003804119,0.003335029,0.02443276],"study_design_scores_gemma":[0.9564665,0.03647514,0.00297397,0.00009535636,0.0006888843,0.000115732,0.00002466917,0.0006494002,0.0003452347,0.0003826635,0.001766017,0.00001646355],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9740793,0.01086482,0.0008420956,0.002127082,0.000663117,0.003091864,0.003147046,0.0002329192,0.004951733],"genre_scores_gemma":[0.9699633,0.004527501,0.003244313,0.003483339,0.0006161607,0.005525195,0.0045361,0.00005506953,0.008049003],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007647701,"threshold_uncertainty_score":0.0255841,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05504110427915776,"score_gpt":0.3896808509919918,"score_spread":0.3346397467128341,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}