{"id":"W4389229326","doi":"10.1182/blood-2023-173147","title":"Safety and Efficacy of Mitapivat in Adult Patients with Erythrocyte Membranopathies (SATISFY)","year":2023,"lang":"en","type":"article","venue":"Blood","topic":"Erythrocyte Function and Pathophysiology","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"","keywords":"Hereditary spherocytosis; Medicine; Anemia; Hemolytic anemia; Jaundice; Pyruvate kinase deficiency; Splenectomy; Hemolysis; Pediatrics; Context (archaeology); Haemolysis; Sickle cell anemia; Internal medicine; Thalassemia; Immunology; Disease; Biology; Pyruvate kinase; Spleen","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008195395,0.0002708164,0.0008225,0.0001586823,0.0001973274,0.0004363092,0.0002372291,0.0005299667,0.001638507],"category_scores_gemma":[0.001693797,0.0001085759,0.0005093116,0.0002293357,0.000212781,0.0003337261,0.0001904102,0.0008900622,0.0002553789],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002514863,"about_ca_system_score_gemma":0.0003404289,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001411125,"about_ca_topic_score_gemma":0.0002454743,"domain_scores_codex":[0.9997292,0.0001239008,0.00003388217,0.00004406947,0.00003923749,0.00002977479],"domain_scores_gemma":[0.9990817,0.0002768805,0.0003467604,0.00004454138,0.00005771585,0.0001922693],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.5269917,0.005731537,0.1187865,0.001698665,0.00215577,0.0008918651,0.0003027328,0.002013498,0.01345428,0.0002858461,0.003872892,0.3238147],"study_design_scores_gemma":[0.1382216,0.4470164,0.390165,0.0004105906,0.002422739,0.003239729,0.0002616814,0.003833598,0.005133971,0.0004453473,0.008790127,0.00005927191],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9904732,0.007207642,0.0002837857,0.0002076672,0.00004388981,0.000158106,0.0005398678,0.00004233206,0.001043412],"genre_scores_gemma":[0.9976569,0.001066849,0.0001627553,0.0002337518,0.00006367162,0.000167643,0.0004249751,0.00000289573,0.0002204716],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001638507,"threshold_uncertainty_score":0.005481362,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007917574580616883,"score_gpt":0.2205227664593017,"score_spread":0.2126051918786848,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}