{"id":"W4389229433","doi":"10.1182/blood-2023-181058","title":"Pharmacokinetic-Guided Hydroxyurea to Reduce Transfusion Requirements in Ugandan Children with Sickle Cell Anemia: Baseline Data from the Alternative Dosing and Prevention of Transfusions (ADAPT) Trial","year":2023,"lang":"en","type":"article","venue":"Blood","topic":"Hemoglobinopathies and Related Disorders","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre Hospitalier Universitaire Sainte-Justine","funders":"","keywords":"Medicine; Dosing; Population; Anemia; Blood transfusion; Sickle cell anemia; Hydroxycarbamide; Pediatrics; Intensive care medicine; Internal medicine; Disease","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002711023,0.0007727204,0.00147053,0.0002786732,0.0004011934,0.000876501,0.0004590389,0.0008631155,0.001708764],"category_scores_gemma":[0.00334088,0.0004047251,0.001263788,0.0004629327,0.0006947459,0.0006560014,0.0005825593,0.002181961,0.0001954181],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005933427,"about_ca_system_score_gemma":0.0009185791,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001071377,"about_ca_topic_score_gemma":0.002040951,"domain_scores_codex":[0.9990035,0.0006631498,0.00007086353,0.00008489037,0.00007153137,0.000106076],"domain_scores_gemma":[0.9982564,0.0004707211,0.0006323564,0.000139792,0.0001422169,0.0003585607],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"observational","study_design_scores_codex":[0.8595219,0.01281955,0.04138132,0.002581607,0.003764884,0.0001918069,0.0005739155,0.001922835,0.001980863,0.0003437482,0.003746426,0.07117115],"study_design_scores_gemma":[0.6599389,0.2311718,0.09493501,0.0008698271,0.003657427,0.0005175305,0.0004087716,0.001400767,0.001179805,0.0006334962,0.005209709,0.00007690328],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.990992,0.005217794,0.0001997327,0.0003073788,0.00008400225,0.0009345466,0.00132724,0.00001784851,0.0009194398],"genre_scores_gemma":[0.9920913,0.002512625,0.0009409405,0.0004898785,0.00009820695,0.002231853,0.001128543,0.000008194741,0.0004985834],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002711023,"threshold_uncertainty_score":0.01433748,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04355201386151078,"score_gpt":0.3173907384408363,"score_spread":0.2738387245793256,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}